115311-40-5

Basic information

• Product Name: 4-Thiazolecarboxylic acid, 2-(2-aMinophenyl)-
• Synonyms: 4-Thiazolecarboxylic acid, 2-(2-aMinophenyl)-
• CAS NO: 115311-40-5
• Molecular Formula: C₁₀H₈N₂O₂S
• Molecular Weight: 220.24772
• Mol File: 115311-40-5.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 4-Thiazolecarboxylic acid, 2-(2-aMinophenyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Thiazolecarboxylic acid, 2-(2-aMinophenyl)-(115311-40-5)
• EPA Substance Registry System: 4-Thiazolecarboxylic acid, 2-(2-aMinophenyl)-(115311-40-5)

Safety Data

• Hazardous Substances Data: 115311-40-5(Hazardous Substances Data)

Upstream product

• 2454-39-9 2-aminobenzothioamide 
• 1885-29-6 anthranilic acid nitrile 

Relevant articles and documents

Total synthesis of anithiactins A-C and thiasporine A

The total syntheses of anithiactins A-C (1–3) and thiasporine A (4) have been achieved in good overall yields. The key reaction in the synthetic sequence was the Suzuki-Miyaura cross-coupling between 2-aminophenylboronic acid hydrochloride and methyl 2-bromothiazole-4-carboxylate forming the common intermediate methyl 2-(2-aminophenyl)thiazole-4-carboxylate (8), which could be further transformed by hydrolysis, alkylation, and aminolysis to give the four title natural products. This work represents the first total synthesis of anithiactin B (2) and C (3).

Thiazoles as inhibitors of 11B-hydroxysteroid dehydrogenase

Provided herein are compounds of the formula (I): as well as pharmaceutically acceptable salts thereof, wherein the substituents are as those disclosed in the specification. These compounds, and the pharmaceutical compositions containing them, are useful for the treatment of diseases such as, for example, type II diabetes mellitus and metabolic syndrome.