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1153574-57-2

(-)-(R)-3-(4-fluoro-2-methylphenyl)-piperazin-2-one is a piperazinone derivative with a molecular formula of C11H14FNO. It is a chemical compound that is commonly used in the pharmaceutical industry for its potential antipsychotic and anxiolytic properties. (-)-(R)-3-(4-fluoro-2-methylphenyl)-piperazin-2-one acts as a selective serotonin 5-HT1A receptor agonist, which is involved in the regulation of mood and anxiety. Its unique structure contains a piperazinone ring attached to a 4-fluoro-2-methylphenyl group, which contributes to its pharmacological activity. Further research and development of (-)-(R)-3-(4-fluoro-2-methylphenyl)-piperazin-2-one could lead to the discovery of new therapies for mental health disorders.
Used in Pharmaceutical Industry:
(-)-(R)-3-(4-fluoro-2-methylphenyl)-piperazin-2-one is used as a selective serotonin 5-HT1A receptor agonist for its potential antipsychotic and anxiolytic properties. Its unique structure and pharmacological activity make it a promising candidate for the development of new therapies for mental health disorders.

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  • 1153574-57-2 Structure

  • Basic information

    1. Product Name: (-)-(R)-3-(4-fluoro-2-methylphenyl)-piperazin-2-one
    2. Synonyms: (-)-(R)-3-(4-fluoro-2-methylphenyl)-piperazin-2-one
    3. CAS NO:1153574-57-2
    4. Molecular Formula:
    5. Molecular Weight: 208.235
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 1153574-57-2.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: N/A
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. CAS DataBase Reference: (-)-(R)-3-(4-fluoro-2-methylphenyl)-piperazin-2-one(CAS DataBase Reference)
    10. NIST Chemistry Reference: (-)-(R)-3-(4-fluoro-2-methylphenyl)-piperazin-2-one(1153574-57-2)
    11. EPA Substance Registry System: (-)-(R)-3-(4-fluoro-2-methylphenyl)-piperazin-2-one(1153574-57-2)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 1153574-57-2(Hazardous Substances Data)

1153574-57-2 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 1153574-57-2 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,1,5,3,5,7 and 4 respectively; the second part has 2 digits, 5 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 1153574-57:
(9*1)+(8*1)+(7*5)+(6*3)+(5*5)+(4*7)+(3*4)+(2*5)+(1*7)=152
152 % 10 = 2
So 1153574-57-2 is a valid CAS Registry Number.

1153574-57-2Downstream Products

1153574-57-2Relevant articles and documents

Iridium-Catalyzed Asymmetric Hydrogenation of Unsaturated Piperazin-2-ones

Wang, Yanzhao,Liu, Yuanyuan,Li, Kun,Yang, Guoqiang,Zhang, Wanbin

, p. 1933 - 1941 (2017/06/09)

Two different iridium catalyst systems, generated from the ruthenocene-based phosphine-oxazoline ligand tBu-mono-RuPHOX or the diphosphine ligand BINAP, were developed for the asymmetric hydrogenation of 5,6-dihydropyrazin-2(1H)-ones, affording chiral piperazin-2-ones in good yields and with moderate to good ees. Different catalytic behaviors for the hydrogenation of these types of substrate were observed with these two catalyst systems. Our tBu-mono-RuPHOX ligand, which bears a ruthenocene scaffold with planar chirality, was found to be the best ligand for the [Ir(L)(COD)]BArF catalyst system, affording the desired products with up to 94% ee. (Figure presented.).

Discovery process and pharmacological characterization of 2-(S)-(4-fluoro-2-methylphenyl)piperazine-1-carboxylic acid [1-(R)-(3,5-bis- trifluoromethylphenyl)ethyl]methylamide (vestipitant) as a potent, selective, and orally active NK1 receptor

Di Fabio, Romano,Griffante, Cristiana,Alvaro, Giuseppe,Pentassuglia, Giorgio,Pizzi, Domenica A.,Donati, Daniele,Rossi, Tino,Guercio, Giuseppe,Mattioli, Mario,Cimarosti, Zadeo,Marchioro, Carla,Provera, Stefano,Zonzini, Laura,Montanari, Dino,Melotto, Sergio,Gerrard, Philip A.,Trist, David G.,Ratti, Emiliangelo,Corsi, Mauro

experimental part, p. 3238 - 3247 (2010/04/03)

In an effort to discover novel druglike NK1 receptor antagonists a new series of suitably substituted C-phenylpiperazine derivatives was identified by an appropriate chemical exploration of related N-phenylpiperazine analogues, with the specifi

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