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3-(4-fluoro-2-methylphenyl)-piperazin-2-one is a chemical compound with the molecular formula C11H12FN2O. It is a derivative of piperazin-2-one, featuring a 4-fluoro-2-methylphenyl group attached to the 3-position of the piperazine ring. 3-(4-fluoro-2-methylphenyl)-piperazin-2-one is known for its potential applications in the pharmaceutical industry, particularly as a building block for the synthesis of various drugs and medicinal agents. Its structure allows for the exploration of different chemical modifications, which can lead to the development of new compounds with specific therapeutic properties. The presence of the fluorine atom and the methyl group on the phenyl ring can significantly influence the compound's reactivity, stability, and biological activity, making it an interesting target for further research and development in the field of medicinal chemistry.

334477-68-8

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334477-68-8 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 334477-68-8 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 3,3,4,4,7 and 7 respectively; the second part has 2 digits, 6 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 334477-68:
(8*3)+(7*3)+(6*4)+(5*4)+(4*7)+(3*7)+(2*6)+(1*8)=158
158 % 10 = 8
So 334477-68-8 is a valid CAS Registry Number.

334477-68-8Relevant articles and documents

Discovery process and pharmacological characterization of 2-(S)-(4-fluoro-2-methylphenyl)piperazine-1-carboxylic acid [1-(R)-(3,5-bis- trifluoromethylphenyl)ethyl]methylamide (vestipitant) as a potent, selective, and orally active NK1 receptor

Di Fabio, Romano,Griffante, Cristiana,Alvaro, Giuseppe,Pentassuglia, Giorgio,Pizzi, Domenica A.,Donati, Daniele,Rossi, Tino,Guercio, Giuseppe,Mattioli, Mario,Cimarosti, Zadeo,Marchioro, Carla,Provera, Stefano,Zonzini, Laura,Montanari, Dino,Melotto, Sergio,Gerrard, Philip A.,Trist, David G.,Ratti, Emiliangelo,Corsi, Mauro

experimental part, p. 3238 - 3247 (2010/04/03)

In an effort to discover novel druglike NK1 receptor antagonists a new series of suitably substituted C-phenylpiperazine derivatives was identified by an appropriate chemical exploration of related N-phenylpiperazine analogues, with the specifi

Synthesis of the NK1 receptor antagonist GW597599. Part 3: Development of a scalable route to a key chirally pure arylpiperazine urea, a happy end

Guercio, Giuseppe,Bacchi, Sergio,Perboni, Alcide,Leroi, Corinne,Tinazzi, Francesco,Bientinesi, Ilaria,Hourdin, Marie,Goodyear, Michael,Curti, Stefano,Provera, Stefano,Cimarosti, Zadeo

scheme or table, p. 1100 - 1110 (2010/04/22)

GW597599 1 is a novel NK-1 antagonist currently under investigation for the treatment of central nervous system disorders and emesis. The initial chemical development synthetic route, derived from the one used by medicinal chemistry, involved several haza

Synthesis of the NK1 receptor antagonist GW597599. Part 1: development of a scalable route to a key chirally pure arylpiperazine

Guercio, Giuseppe,Bacchi, Sergio,Goodyear, Michael,Carangio, Antonella,Tinazzi, Francesco,Curti, Stefano

, p. 1188 - 1194 (2013/01/03)

GW5975991 is a novel NK-1 antagonist currently under investigation for the treatment of CNS disorders and emesis. The initial synthetic route devised from the medicinal chemistry one, used several hazardous reagents, gave low yields, and produced high lev

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