1153594-93-4Relevant academic research and scientific papers
On-water reactivity and regioselectivity of quinones in C-N coupling with amines: Experimental and theoretical study
Martinez-Cifuentes, Maximiliano,Clavijo-Allancan, Graciela,Di Vaggio-Conejeros, Carolina,Weiss-Lopez, Boris,Araya-Maturana, Ramiro
, p. 217 - 224 (2014/03/21)
A study about the oxidative coupling of some representative carbo-and heterocyclic non-symmetrical quinones with aryl-and alkylamines, was carried out comparing dichloromethane and water as reaction mediums. We found that the on-water reactions gave better or, at worst, the same results as a conventional organic medium like dichloromethane. Descriptors derived from conceptual density functional theory and approaches of electrostatic nature, such as the molecular electrostatic potential, were used to explain the observed chemical reactivity and regioselectivity. Further, the on-water conditions were used to obtain 24 new aminoquinones with potential biological activity.
Studies on quinones. Part 45: Novel 7-aminoisoquinoline-5,8-quinone derivatives with antitumor properties on cancer cell lines
Valderrama, Jaime A.,Andrea Ibacache,Arancibia, Veronica,Rodriguez, Jaime,Theoduloz, Cristina
experimental part, p. 2894 - 2901 (2009/09/06)
A variety of 7-aminoisoquinoline-5,8-quinone derivatives were prepared from 2,5-dihydroxyacetophenone, methyl aminocrotonate, and the corresponding amines, through a highly efficient three-step sequence. The members of this series were tested on normal hu
