1153687-22-9Relevant academic research and scientific papers
Palladium-catalysed intramolecular direct arylation of 2- bromobenzenesulfonic acid derivatives
Bheeter, Charles Beromeo,Bera, Jitendra K.,Doucet, Henri
, p. 3533 - 3538 (2013/02/26)
A palladium-catalysed intramolecular direct arylation of 2-bromobenzenesulfonic acid derivatives was found to proceed using 1 mol% of palladium acetate as the catalyst. The influence of the substituents on the phenol moiety of 2-bromobenzenesulfonic acid phenyl esters reveals that electron-donating substituents favour the reaction while electron-withdrawing ones are unfavourable. The reactivity of sulfonamides was also studied and, in all cases, a selective activation at sp2 C-H vs. sp3 C-H was observed. A sulfonamide bearing both phenyl and benzyl substituents on nitrogen gave selectively the six-membered ring product.
α-Haloarylsulfonamides: multiple cyclization pathways to skeletally diverse benzofused sultams
Rayabarapu, Dinesh Kumar,Zhou, Aihua,Jeon, Kyu Ok,Samarakoon, Thiwanka,Rolfe, Alan,Siddiqui, Hina,Hanson, Paul R.
experimental part, p. 3180 - 3188 (2009/08/15)
The development of new methods to skeletally diverse sultams based on a central α-halo benzene sulfonamide building block is reported. Several salient features of this building block are utilized in multiple reaction pathways, including the Heck reaction, C- and O-arylation, Sonogashira-Pauson-Khand, Sonogashira-intramolecular hydroamination, and domino aza-Michael-Heck for the generation of five-, six-, and seven-membered benzofused bicyclic and tricyclic sultams.
