115377-03-2Relevant academic research and scientific papers
Synthesis of iodoalkylidene lactones from alkenes
Haaima,Lynch,Routledge,Weavers
, p. 4229 - 4252 (2007/10/02)
Alkenes are reality transformed into iodo acetylenic esters by addition of acetylenic acids in the presence of a source of iodonium ion. A subsequent free-radical cyclisation induced by dibenzoyl peroxide leads to (E)-iodoalkylidene butyrolactones.
IODOVINYLIDENE LACTONE SYNTHESIS. FREE RADICAL CYCLISATION OF IODO ACETYLENIC ESTERS.
Haaima, Gerald,Weavers, Rex T.
, p. 1085 - 1088 (2007/10/02)
Propiolic acids add to alkenes in the presence of N-iodosuccinimide to give iodo acetylenic esters.These, on treatment with dibenzoyl peroxide, undergo cyclisation to yield (E)-iodovinylidene butyrolactones.Subsequent alkylation with lithium dimethylcuprate occurs by replacement of the iodine.
