115393-37-8Relevant articles and documents
STEREOCHEMICAL STUDIES, 105. SATURATED HETEROCYCLES, 109 SYNTHESIS AND STERIC STRUCTURES OF PERHYDRO-4,1-BENZOXAZEPIN-2-ONES
Bernath, Gabor,Fueloep, Ferenc,Sohar, Pal
, p. 4359 - 4366 (1987)
-cis- and trans-2-Hydroxymethylcyclohexanol were cyclized with ethyl chloroacetate or ethyl 2-chloropropionate in the presence of sodium hydride to synthesize stereoisomeric perhydro-4,1-benzoxazepin-2-ones (4-9).The relative configurations and predominant conformation of the compounds prepared were confirmed by 1H and 13C NMR spectroscopy.