1153949-71-3Relevant academic research and scientific papers
Deracemization of axially chiral α,β-unsaturated aldehydes through an amino-catalyzed symmetry-making-symmetry-breaking cascade
Jiang, Hao,Halskov, Kim Soholm,Johansen, Tore Kiilerich,Jorgensen, Karl Anker
supporting information; experimental part, p. 3842 - 3846 (2011/05/07)
Highly enantioenriched products have been prepared in good yields from racemic enal starting materials through a new deracemization strategy that employs an enantioconvergent amino-catalyzed symmetry-making-symmetry-breaking cascade. The reaction design features the tandem domination of product development and catalyst control in two reaction steps (see scheme).
4-PYRAZOLYL-N-ARYLPYRIMIDIN-2-AMINES AND 4-PYRAZOLYL-N-HETEROARYLPYRIMIDIN-2-AMINES AS JANUS KINASE INHIBITORS
-
Page/Page column 128, (2009/06/27)
The present invention provides substituted bicyclic heteroaryl compounds, 5 including, for example, 4-pyrazoIyI-N-arylpyrirnidin-2-arnines and 4-pyrazolyl-N-heteroarylpyτimidin-2-amines that modulate the activity of kinases and are useful in the treatment of diseases related to activity of kinases including, for example, immune-related diseases, skin disorders, myeloid proliferative disorders, cancer, and other diseases.formule :(1)
