55145-45-4

Basic information

• Product Name: 4-(TERT-BUTYLDIMETHYLSILYLOXY)CYCLOHEXA&
• Synonyms: 4-(tert-ButyldiMethylsilyloxy)cyclohexanone 97%;4-[[(1,1-dimethylethyl)dimethylsilyl]oxy]Cyclohexanone;4-(tert-ButyldimEtsilyloxy)cyclohexanone;4-(tert-Butyldimethylsilyloxy)cyclohexanone (meso form);4-((tert-Butyldimethylsilyl);4-(TERT-BUTYLDIMETHYLSILYLOXY)CYCLOHEXA&;4-(TERT-BUTYLDIMETHYLSILOXY)CYCLOHEXANO&;4-(tert-Butyl-dimethyl-silanyloxy)-cyclohexanone
• CAS NO: 55145-45-4
• Molecular Formula: C₁₂H₂₄O₂Si
• Molecular Weight: 228.406
• Product Categories: C11 to C12;Carbonyl Compounds;Ketones
• Mol File: 55145-45-4.mol
• Article Data: 18

Chemical Properties

• Boiling Point: 85 °C1 mm Hg(lit.)
• Flash Point: >230 °F
• Appearance: Clear colorless to yellow/Liquid
• Density: 0.909 g/mL at 25 °C(lit.)
• Vapor Pressure: 0.011mmHg at 25°C
• Refractive Index: n20/D 1.4530(lit.)
• CAS DataBase Reference: 4-(TERT-BUTYLDIMETHYLSILYLOXY)CYCLOHEXA&(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(TERT-BUTYLDIMETHYLSILYLOXY)CYCLOHEXA&(55145-45-4)
• EPA Substance Registry System: 4-(TERT-BUTYLDIMETHYLSILYLOXY)CYCLOHEXA&(55145-45-4)

Safety Data

• WGK Germany: 3
• Hazardous Substances Data: 55145-45-4(Hazardous Substances Data)

Usage

General Description

4-(tert-butyldimethylsilyloxy)cyclohexane is a chemical compound that belongs to the family of cycloalkanes. It is a derivative of cyclohexane with a tert-butyldimethylsilyloxy group attached to one of the carbon atoms. 4-(TERT-BUTYLDIMETHYLSILYLOXY)CYCLOHEXA& is commonly used as a protecting group in organic synthesis, particularly in the protection of hydroxyl groups during chemical reactions. The tert-butyldimethylsilyloxy group provides steric hindrance and protects the hydroxyl group from unwanted reactions, allowing for selective manipulation of other functional groups. It is also used in the synthesis of various pharmaceuticals and agrochemicals.

InChI:InChI=1/C12H24O2Si/c1-12(2,3)15(4,5)14-11-8-6-10(13)7-9-11/h11H,6-9H2,1-5H3

Upstream product

• 556-48-9 1,4-Cyclohexanediol 
• 18162-48-6 tert-butyldimethylsilyl chloride 
• 22428-87-1 4,4-ethylenedioxycyclohexan-1-ol 
• 4746-97-8 cyclohexanedione monoethylene ketal 
• 126931-29-1 4-((tert-butyldimethylsilyl)oxy)cyclohexan-1-ol 
• 112906-39-5 8-[(tert-butyldimethylsilyl)oxy]-1,4-dioxaspiro[4,5]decane 
• 154410-54-5 tert-Butyl-[2-(4-methoxy-phenyl)-1,4-dioxa-spiro[4.5]dec-8-yloxy]-dimethyl-silane 
• 124414-01-3 tert-butyl[(4,4-dimethoxycyclohexyl)oxy]dimethylsilane 
• 13482-22-9 4-hydroxycyclohexanone 

Downstream Products

• 110852-37-4 ethyl (4-((tert-butyldimethylsilyl)oxy)cyclohexylidene)acetate 
• 154410-54-5 tert-Butyl-[2-(4-methoxy-phenyl)-1,4-dioxa-spiro[4.5]dec-8-yloxy]-dimethyl-silane 
• 388570-48-7 [5-(tert-butyl-dimethyl-silanyloxy)-2-oxo-cyclohexyl]-acetonitrile 
• 569330-35-4 N'-{4-[(tert-butyldimethylsilyl)oxy]cyclohexylidene}-4-methylbenzene-1-sulfonohydrazide 
• 849071-55-2 cis-1,4-dihydroxycyclohexanecarbonitrile 
• 1220393-31-6 C₁₉H₃₃NOSi 
• 1246655-00-4 ethyl 5-(tert-butyldimethylsilyloxy)-1-(iodomethyl)-2-oxocyclohexanecarboxylate 
• 110852-23-8 2-(4-(tert-butyldimethylsilyloxy)cyclohexylidene)acetaldehyde 
• 119414-47-0 (+/-)-4-(tert-butyl(dimethyl)silyloxy)-2-cyclohexen-1-one 
• 1393641-21-8 ethyl cis-2-diazo-2-(4-(tert-butyldimethylsilyloxy)-1-hydroxycyclohexyl)acetate 
• 1393641-23-0 ethyl trans-2-diazo-2-(4-(tert-butyldimethylsilyloxy)-1-hydroxycyclohexyl)acetate 
• 1350444-85-7 {2-fluoro-4-[4-((S)-2-methyl-pyrrolidin-1-yl)-cyclohex-1-enyl]-phenyl}-carbamic acid benzyl ester 

Relevant articles and documents

AMINOPYRIMIDINE COMPOUND

The present invention provides a compound having a CaMKII inhibitory action, which is expected to be useful as an agent for the prophylaxis or treatment of cardiac diseases (particularly catecholaminergic polymorphic ventricular tachycardia, postoperative atrial fibrillation, heart failure, fatal arrhythmia) and the like. The present invention relates to a compound represented by the formula (I): wherein each symbol is as defined in the specification, or a salt thereof.

Construction of Distant Stereocenters by Enantioselective Desymmetrizing Carbonyl-Ene Reaction

An efficient desymmetrizing carbonyl-ene reaction of 1-substituted 4-methylenecyclohexanes with glyoxal derivatives was thus executed by a chiral N,N′-dioxide/NiII catalyst, providing facile access to cyclohexene derivatives bearing two remote 1,6-related stereocenters. This distal stereocontrol methodology originates from the efficient interaction between the catalyst with enophiles, discrimination of the two chair conformations of olefinic components, and the intrinsic six-membered transition-state structure of ene process.

Various oxidative reactions with novel ion-supported (diacetoxyiodo) benzenes

The oxidation of secondary alcohols and primary alcohols with two novel ion-supported (diacetoxyiodo)benzenes (IS-DIBs) A and B in the presence of a catalytic amount of 2,2,6,6-tetramethylpiperidine-1-oxyl radical (TEMPO) in dichloromethane at room temperature proceeded efficiently to provide the corresponding ketones and aldehydes, respectively, in good yields. The oxidative reaction of N,N-diisopropylbenzylamines with those IS-DIBs was also carried out to generate the corresponding aromatic aldehydes in good yields. In addition, the Hofmann rearrangement of primary amides in methanol under basic conditions and the oxidative 1,2-rearrangement of propiophenones in trimethyl orthoformate under acidic conditions with those IS-DIBs provided the corresponding methyl carbamates and methyl 2-arylpropanoates, respectively, in good yields. Moreover, treatment of acetophenones with those IS-DIBs in the presence of trifluoromethanesulfonic acid in acetonitrile generated the corresponding 5-aryl-2-methyloxazoles in good yields. In those five reactions, the desired products were obtained in good yields with high purity by simple extraction of the reaction mixture with diethyl ether and subsequent removal of the solvent from the extract. Moreover, ion-supported iodobenzenes, which were the co-products derived from IS-DIBs in the present oxidative reactions, were recovered in good yields and could be re-oxidized to IS-DIBs A and B for reuse in the same oxidative reactions.