115395-14-7Relevant articles and documents
A solvent-dependent chirality-switchable thia-Michael addition to α,β-unsaturated carboxylic acids using a chiral multifunctional thiourea catalyst
Hayama, Noboru,Inamoto, Kiyofumi,Kimachi, Tetsutaro,Kobayashi, Yusuke,Miyazaki, Anna,Sekimoto, Eriko,Takemoto, Yoshiji
, p. 5572 - 5576 (2020)
An asymmetric thia-Michael addition of arylthiols to α,β-unsaturated carboxylic acids using a thiourea catalyst that bears arylboronic acid and tertiary amine moieties is reported. Both enantiomers of the Michael adducts can be obtained in high enantioselectivity and good yield merely by changing the solvent. The origin of the chirality switch in the products was examined in each solventviaspectroscopic analyses.
A novel chemoenzymatic enantioselective synthesis of some clinically effective CNS drugs and related compounds
Kumar, Ashok,Ner, D H,Dike, Suneel
, p. 803 - 809 (2007/10/02)
We have demonstrated in this study a novel route for the synthesis of benzothiopyran and benzothiazepin ring systems along with the synthesis of optically pure, clinically effective drugs tomoxetine, fluoxetine and thiazesim.
