1154-25-2 Usage
Description
Sodium-hydrogen exchangers (NHE) are involved in maintaining sodium and pH balance in a variety of tissues. They are also known as sodium-hydrogen antiporters and solute carrier family 9 members. 5-(N-ethyl-N-isopropyl)-Amiloride (EIPA) is a potent inhibitor of several NHE isoforms, inhibiting NHE1, NHE2, NHE3, and NHE5 with Ki values of 0.02, 0.5, 2.4, and 0.42 μM, respectively. It less effectively inhibits NHE4 (IC50 ≥10 μM). EIPA is commonly used at a concentration of 5-10 μM to inhibit cellular HNE activity.
Chemical Properties
Yellow Solid
Uses
Different sources of media describe the Uses of 1154-25-2 differently. You can refer to the following data:
1. Selective Na+/H+ antiporter inhibitor. Selectively enhances the excretion of sodium ions without causing an increase in excretion of potassium ions.
2. 5-(N-Ethyl-N-isopropyl)amiloride has been used:as a supplement in endothelial cell growth medium to incubate human lung microvascular endothelial cellin Pluronic F-127 stock solution for Drosophila larval live-imagingin choline chloride solution as an experimental perfusate, to study the effect of Na+/H+ inhibition on jejunal loop perfusion in vivo
3. Selective Na+/H+ antiporter inhibitor. Selectively enhances the excretion of sodium ions without causing an increase in excretion of potassium ions
Biochem/physiol Actions
Selective blocker of Na+/H+ antiport
Check Digit Verification of cas no
The CAS Registry Mumber 1154-25-2 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 1,1,5 and 4 respectively; the second part has 2 digits, 2 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 1154-25:
(6*1)+(5*1)+(4*5)+(3*4)+(2*2)+(1*5)=52
52 % 10 = 2
So 1154-25-2 is a valid CAS Registry Number.
InChI:InChI=1/C11H18ClN7O/c1-4-19(5(2)3)9-7(12)16-6(8(13)17-9)10(20)18-11(14)15/h5H,4H2,1-3H3,(H2,13,17)(H4,14,15,18,20)
