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EIPA, also known as 5-(N-ethyl-N-isopropyl)-amiloride, is a potent inhibitor of sodium-hydrogen exchangers (NHE), which are involved in maintaining sodium and pH balance in various tissues. It selectively inhibits NHE1, NHE2, NHE3, and NHE5 isoforms with Ki values of 0.02, 0.5, 2.4, and 0.42 μM, respectively, and less effectively inhibits NHE4 (IC50 ≥10 μM). EIPA is commonly used at a concentration of 5-10 μM to inhibit cellular NHE activity and is a yellow solid.

1154-25-2

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1154-25-2 Usage

Uses

Used in Biological Research:
EIPA is used as a selective Na+/H+ antiporter inhibitor for studying the role of NHE in various biological processes. It selectively enhances the excretion of sodium ions without causing an increase in the excretion of potassium ions.
Used in Cell Culture:
EIPA is used as a supplement in endothelial cell growth medium to incubate human lung microvascular endothelial cells in Pluronic F-127 stock solution.
Used in Drosophila Larval Live-Imaging:
EIPA is used in choline chloride solution as an experimental perfusate to study the effect of Na+/H+ inhibition on jejunal loop perfusion in vivo.
Used in In Vivo Studies:
EIPA is used as an experimental perfusate in choline chloride solution to study the effect of Na+/H+ inhibition on jejunal loop perfusion in vivo.

Biochem/physiol Actions

Selective blocker of Na+/H+ antiport

Check Digit Verification of cas no

The CAS Registry Mumber 1154-25-2 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 1,1,5 and 4 respectively; the second part has 2 digits, 2 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 1154-25:
(6*1)+(5*1)+(4*5)+(3*4)+(2*2)+(1*5)=52
52 % 10 = 2
So 1154-25-2 is a valid CAS Registry Number.
InChI:InChI=1/C11H18ClN7O/c1-4-19(5(2)3)9-7(12)16-6(8(13)17-9)10(20)18-11(14)15/h5H,4H2,1-3H3,(H2,13,17)(H4,14,15,18,20)

1154-25-2SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 20, 2017

Revision Date: Aug 20, 2017

1.Identification

1.1 GHS Product identifier

Product name 5-(N-Ethyl-N-isopropyl) Amiloride

1.2 Other means of identification

Product number -
Other names 3-amino-6-chloro-N-(diaminomethylidene)-5-[ethyl(propan-2-yl)amino]pyrazine-2-carboxamide

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:1154-25-2 SDS

1154-25-2Upstream product

1154-25-2Downstream Products

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