1154-58-1

Upstream product

• 526-02-3 3-[2-(2-hyroxy-3,5-dimethylphenyl)-2-oxoethyl] glutarimide 
• 170807-02-0 4-[2-(2-Chloro-3,5-dimethyl-6-oxo-cyclohex-1-enyl)-2-oxo-ethyl]-piperidine-2,6-dione 

Downstream Products

• 66-81-9 Cycloheximide 

Relevant academic research and scientific papers

Cycloheximide and actiphenol production in streptomyces sp. YIM56141 governed by single biosynthetic machinery featuring an acyltransferase-less type i polyketide synthase

Cycloheximide (1) and actiphenol (2) have been isolated from numerous Streptomyces species. Cloning, sequencing, and characterization of a gene cluster from Streptomyces sp. YIM65141 now establish that 1 and 2 production is governed by single biosynthetic machinery. Biosynthesis of 1 features an acyltransferase-less type I polyketide synthase to construct its carbon backbone but may proceed via 2 as a key intermediate, invoking a provocative reduction of a phenol to a cyclohexanone moiety in natural product biosynthesis.

Synthesis of dehydro derivatives of cycloheximide and inactone

Catalytic hydrogenation of 3-chloro-2-(2,6-dioxopiperidin-4-ylacetyl)-2-cyclohexenones over palladium catalyst leads to formation of dehydrocycloheximide derivatives. Reduction of the same compounds with Zn-Ag yields dehydroinactone derivatives.