1154062-14-2

Upstream product

• 916525-71-8 (1R,2S)-1,2-bis(2-methoxyphenyl)-2-(2-methylpropoxy)ethanol 
• 814-68-6 acryloyl chloride 

Downstream Products

• 1154062-17-5 bicyclo[2.2.1]hept-5-ene-2-carboxylic acid (1R,2S)-1,2-bis(2-methoxyphenyl)-2-(2-methylpropoxy)ethyl ester 
• 1237738-32-7 (2R,4S,5R)-2,5-diphenylpyrrolidine-2,4-dicarboxylic acid 4-[(1R,2S)-1,2-di(2-methoxyphenyl)-2-(2-methylpropoxy)ethyl] ester 2-methyl ester 

Relevant academic research and scientific papers

Application of meso-hydrobenzoin-derived chiral auxiliaries for the stereoselective synthesis of highly substituted pyrrolidines by 1,3-dipolar cycloaddition of azomethine ylides

The metal-catalyzed stereoselective 1,3-dipolar cycloaddition of azomethine ylides and acrylates using recyclable meso-hydrobenzoin-derived chiral auxiliaries is described. Cleavage of the auxiliary leads to highly substituted pyrrolidines in up to 87% en

Chiral linker 5: scope and limitations of arylsubstituted m-hydrobenzoins as solid supported open chain chiral auxiliaries for diastereoselective syntheses

The applicability of five aryl substituted m-hydrobenzoin ethers already tested in the L-Selectride mediated stereoselective reduction of phenylglyoxylates as open chain chiral auxiliaries was further investigated via the α-alkylation of propionates, the addition of n-BuZnCl to phenylglyoxylates and the Diels-Alder reaction of acrylates with cyclopentadiene as model reactions. As up to 90% de could be achieved in the solution phase, two optimized auxiliary structures were immobilized on commercially available Wang-resin and applied as a reusable solid supported chiral auxiliaries in the same type of reactions.