1154063-22-5Relevant academic research and scientific papers
Enantioselective Aza-Reformatsky Reaction with Ketimines
Maestro, Aitor,Martinez De Marigorta, Edorta,Palacios, Francisco,Vicario, Javier
, p. 9473 - 9477 (2019/11/28)
Here, an enantioselective aza-Reformatsky reaction using acyclic ketimine substrates is presented. Using α-phosphorated ketimines as electrophilic substrates and a simple BINOL-derived ligand, phosphorated analogues of aspartic acid holding chiral tetrasubstituted carbons are efficiently obtained with excellent enantioselectivity through an asymmetric organocatalytic Reformatsky-type reaction. The phosphorated analogues of aspartic acid have been used for the synthesis of phosphorus-containing enantiopure tetrasubstituted β-lactams.
Nucleophilic carbene-mediated hydrophosphonylation of aldimines
Cai, Zhi-Hua,Du, Guang-Fen,Dai, Bin,He, Lin
supporting information; experimental part, p. 694 - 698 (2012/04/10)
Aldimines undergo efficient hydrophosphonylation reactions with dimethyl phosphite in the presence of nucleophilic heterocyclic- carbenes (NHCs) as organocatalysts to give the corresponding (α-aminoalkyl)phosphonates in moderate-to-excellent yields. Georg
Hydrophosphonylation of aldimines under catalysts-free conditions
Cai, Zhihua,Fan, Yecheng,Du, Guangfen,He, Lin
experimental part, p. 1658 - 1662 (2012/09/07)
Trimethylsilyl phosphite reacted with aldimines efficiently under catalysts-free conditions, giving α-aminophosphonates in good to excellent yields. Furthermore, the reaction can be scaled-up easily and the high yield can be maintained. Copyright
Amberlyst-15-catalyzed facile synthesis of α-amino phosphonates
Sudhakar, Dega,Siddaiah, Vidavalur,Venkata Rao, Chunduri
experimental part, p. 976 - 980 (2011/04/24)
(Chemical Equation Presented) A simple and efficient method has been developed for the synthesis of sulfonamide phosphonates from N-tosyl aldimines and dimethyl trimethylsilyl phosphite at 0 °C in the presence of Amberlyst-15 as a heterogeneous catalyst.
Iodine-catalyzed efficient hydrophosphonylation of N-tosyl aldimines
Das, Biswanath,Balasubramanyam, Penagaluri,Krishnaiah, Maddeboina,Veeranjaneyulu, Boyapati,Reddy, Gandolla Chinna
supporting information; experimental part, p. 4393 - 4395 (2009/09/06)
(Chemical Equation Presented) Treatment of N-tosyl aldimines with dialkyl trimethylsilyl phosphites at 0°C in the presence of iodine as a catalyst afforded the corresponding sulfonamide phosphonates in excellent yields within 1.5 to 2.5 h.
