115436-75-4Relevant academic research and scientific papers
Selective fries rearrangement catalyzed by zinc powder
Paul, Satya,Gupta, Monika
, p. 1789 - 1792 (2007/10/03)
Zinc powder in the presence of N,N-dimethylformamide efficiently catalyzes the selective Fries rearrangement of acetylated phenols under microwave heating or with conventional heating using an oil bath. In some cases different products were obtained using microwave heating and conventional heating. Selective migration of the acyl group has been noted with good yields.
Reaction of Acetic Anhydride/Zinc Chloride Reagent with Phenols: Improved Yields of Hydroxyacetophenones
Anjaneyulu, A. S. R.,Mallavadhani, U. V.,Venkateswarlu, Y.,Prasad, A. V. Rama
, p. 823 - 826 (2007/10/02)
Acetic anhydride/zinc chloride has been found to be a better acylating system for phenol and polyphenols resulting in improved yields of the respective hydroxyacetophenones.The phenols used are phenol, resorcinol, hydroquinonone, catechol, phloroglucinol and pyrogallol.With resorcinol the isomeric diacetyl derivatives are formed in excellent yields in a single step, while catechol and hydroquinone give only monoacetyl derivatives like simple phenol.Pyrogallol gives a monoacetyl derivative while phloroglucinol gives both mono and diacetyl derivatives but not triacetyl derivatives.
