1154574-50-1

Basic information

• Product Name: 3-(4-benzylpiperidin-1-yl)-4-chloro-1,2,5-thiadiazole
• Synonyms: 3-(4-benzylpiperidin-1-yl)-4-chloro-1,2,5-thiadiazole;4-Benzyl-1-(4-chloro-[1,2,5]thiadiazol-3-yl)-piperidine
• CAS NO: 1154574-50-1
• Molecular Formula: C14H16ClN3S
• Molecular Weight: 293.81494
• Mol File: 1154574-50-1.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 406.8±30.0 °C(Predicted)
• Appearance: /
• Density: 1.289±0.06 g/cm3(Predicted)
• PKA: 1.07±0.49(Predicted)
• CAS DataBase Reference: 3-(4-benzylpiperidin-1-yl)-4-chloro-1,2,5-thiadiazole(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(4-benzylpiperidin-1-yl)-4-chloro-1,2,5-thiadiazole(1154574-50-1)
• EPA Substance Registry System: 3-(4-benzylpiperidin-1-yl)-4-chloro-1,2,5-thiadiazole(1154574-50-1)

Safety Data

• Hazardous Substances Data: 1154574-50-1(Hazardous Substances Data)

Usage

Chemical compound

3-(4-benzylpiperidin-1-yl)-4-chloro-1,2,5-thiadiazole

Properties

Potential pharmacological properties

Composition

Contains a piperidine ring and a chloro-thiadiazole moiety

Potential uses

Pharmaceutical research and development, potential candidate for drug development

Functional groups

Benzylpiperidine group and chloro-thiadiazole moiety

Impact

Benzylpiperidine group can contribute to binding affinity to certain receptors, chloro-thiadiazole moiety can enhance bioactivity

Applications

Potential new drug development for neurological disorders, cardiovascular diseases, and cancer

Need for further studies

Required to fully understand pharmacological properties and potential uses

Upstream product

• 31252-42-3 4-benzylpyperidine 
• 5728-20-1 3,4-dichloro-1,2,5-thiadiazole 

Relevant articles and documents

Optimization of 1,2,5-thiadiazole carbamates as potent and selective ABHD6 inhibitors

At present, inhibitors of α/β-hydrolase domain 6 (ABHD6) are viewed as a promising approach to treat inflammation and metabolic disorders. This article describes the development of 1,2,5-thiadiazole carbamates as ABHD6 inhibitors. Altogether, 34 compounds were synthesized, and their inhibitory activity was tested using lysates of HEK293 cells transiently expressing human ABHD6 (hABHD6). Among the compound series, 4-morpholino-1,2,5-thiadiazol-3-yl cyclooctyl(methyl)carbamate (JZP-430) potently and irreversibly inhibited hABHD6 (IC50 = 44 nM) and showed ～ 230-fold selectivity over fatty acid amide hydrolase (FAAH) and lysosomal acid lipase (LAL), the main off-targets of related compounds. Additionally, activity-based protein profiling indicated that JZP-430 displays good selectivity among the serine hydrolases of the mouse brain membrane proteome. JZP-430 has been identified as a highly selective, irreversible inhibitor of hABHD6, which may provide a novel approach in the treatment of obesity and type II diabetes.