5728-20-1 Usage
Uses
Used in Pharmaceutical Industry:
3,4-Dichloro-1,2,5-thiadiazole is used as a building block for the preparation of the β-adrenergic blocking agent, Timolol (T443700), which is an essential medication for treating conditions like hypertension, angina, and certain heart rhythm disorders.
Used in Chemical Research:
3,4-Dichloro-1,2,5-thiadiazole serves as a guest molecule to investigate solid-state 13C NMR spectra of inclusion compounds of 2,6-dimethyl-bicyclo[3.3.1]nonane-exo-2-exo-6-diol with small organic molecules. This application aids in understanding the structural and chemical properties of these compounds.
Used in Agricultural Industry:
3,4-Dichloro-1,2,5-thiadiazole is used as a potent inhibitor of nitrification in soil, which can help control the conversion of ammonia to nitrate, thereby managing nitrogen levels and potentially reducing environmental pollution from excess nitrogen compounds.
Used in Organic Synthesis:
3,4-Dichloro-1,2,5-thiadiazole is employed in the preparation of [1,2,5]thiadiazol-3-yl-piperazine compounds, which have potential applications in various fields, including pharmaceuticals and materials science.
Chemical Properties:
3,4-Dichloro-1,2,5-thiadiazole is a colorless liquid, which makes it suitable for use in various chemical reactions and processes.
Synthesis Reference(s)
Tetrahedron Letters, 15, p. 1687, 1974 DOI: 10.1016/S0040-4039(01)82554-5
Check Digit Verification of cas no
The CAS Registry Mumber 5728-20-1 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 5,7,2 and 8 respectively; the second part has 2 digits, 2 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 5728-20:
(6*5)+(5*7)+(4*2)+(3*8)+(2*2)+(1*0)=101
101 % 10 = 1
So 5728-20-1 is a valid CAS Registry Number.
InChI:InChI=1/C2Cl2N2S/c3-1-2(4)6-7-5-1
5728-20-1Relevant academic research and scientific papers
Strunskaya,Bredikhina,Azancheev,Bredikhin
, p. 1330 - 1334 (2001)
3-Aryloxy-1,2,5-thiadiazoles were synthesized by the Ullmann reaction either from 3-chloro-1,2,5-thiadiazoles and phenols having donor substituents or from 3-hydroxy-1,2,5-thiadiazoles and chlorobenzenes containing acceptor substituents.
1,2,5-Thiadiazole 2-oxides: Selective synthesis, structural characterization, and electrochemical properties
Konstantinova, Lidia S.,Knyazeva, Ekaterina A.,Obruchnikova, Natalia V.,Vasilieva, Nadezhda V.,Irtegova, Irina G.,Nelyubina, Yulia V.,Bagryanskaya, Irina Yu.,Shundrin, Leonid A.,Sosnovskaya, Zhanna Yu.,Zibarev, Andrey V.,Rakitin, Oleg A.
, p. 5558 - 5568 (2015/03/30)
A new general procedure for the selective synthesis of 1,2,5-thiadiazole 2-oxides (including fused derivatives) 8a,b,c,g,h from the reaction of vic-glyoximes with S2Cl2 and pyridine in acetonitrile was elaborated together with general procedure for the synthesis of 1,2,5-thiadiazoles 7a-i, 10, 12, and 14 from the same starting materials and reagents. Molecular structures of 3,4-dimethyl-1,2,5-thiadiazole 2-oxide 8a and [1,2,5]thiadiazolo[3,4-b]quinoxaline 10 were confirmed by single-crystal X-ray diffraction. Electrochemical properties of 1,2,5-thiadiazole 2-oxides 8 were studied by cyclic voltammetry and different behavior was observed for monocyclic and benzo-fused derivatives. With compounds 8g and 17, previously unknown deoxygenation of 2,1,3-benzothiadiazole 1-oxides was discovered by electrochemical reduction, and resulted 2,1,3-benzothiadiazoles 7g and 19 were detected in the forms of their radical anions by EPR spectroscopy combined with DFT calculations.
