1154623-23-0Relevant academic research and scientific papers
Total synthesis of the akuammiline alkaloid picrinine
Smith, Joel M.,Moreno, Jesus,Boal, Ben W.,Garg, Neil K.
, p. 4504 - 4507 (2014)
We report the first total synthesis of the complex akuammiline alkaloid picrinine, which was first isolated nearly five decades ago. Our synthetic approach features a concise assembly of the [3.3.1]-azabicyclic core, a key Fischer indolization reaction to forge the natural product's carbon framework, and a series of delicate late-stage transformations to complete the synthesis. Our synthesis of picrinine also constitutes a formal synthesis of the related polycyclic alkaloid strictamine.
