115475-74-6

Upstream product

• 74510-40-0 N-(2-methoxy-4-methylphenyl)pivalamide 
• 147699-89-6 N-acetyl-3-methoxy-5-methyl anthranilic acid 
• 147699-88-5 N-acetyl-2-bromo-6-methoxy p-toluidine 
• 147699-87-4 2-bromo-6-methoxy-p-toluidine 
• 106-49-0 p-toluidine 
• 6968-24-7 2,6-Dibromo-4-methylaniline 

Downstream Products

• 155722-67-1 3-bromo-2-(2-methoxycarbonyl-6-methoxy-4-methyl)phenyljuglone 
• 155722-68-2 2-(2-methoxycarbonyl-6-methoxy-4-methyl)phenyljuglone 
• 76191-52-1 WS-5995 B 
• 155722-63-7 3-bromo-2-(2-methoxycarbonyl-6-methoxy-4-methyl)phenyl-5,6,7,8-tetrahydrojuglone 

Relevant academic research and scientific papers

A new convergent synthesis of WS-5995-B, an anticoccidial antibiotic from Streptomyces auranticolor

A new synthesis of WS-5995-B, an anticoccidial antibiotic isolated from Streptomyces auranticolor is reported via the coupling reaction between 3-bromo-5,6,7,8-tetrahydrojuglone, and 3-methoxy-5-methyl anthranilic acid. A simple method for the preparation of the anthranilate 7 starting from p-toluidine by shorter sequence is reported.

Synthesis of The Gilvocarcin-M Aglycone

The synthesis of the aglycone of the antibiotic Gilvocarcin-M by a sequential Meerwein Diels-Alder route is reported.The D-ring of the aglycone is attached by a halogen atom directed Meerwein arylation reaction and the A-ring is attached by a halogen atom directed Diels-Alder reaction.In the key step the directing chlorine atom is removed by a new thiophenylation reduction sequence.