115481-73-7

Basic information

• Product Name: bis(4-hydroxyphenyl)(2-(phenoxysulfonyl)phenyl)methane
• Synonyms: bis(4-hydroxyphenyl)(2-(phenoxysulfonyl)phenyl)methane
• CAS NO: 115481-73-7
• Molecular Formula: C₂₅H₂₀O₅S
• Molecular Weight: 432.49
• Mol File: 115481-73-7.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 640.5°Cat760mmHg
• Flash Point: 341.2°C
• Appearance: /
• Density: 1.338g/cm³
• Vapor Pressure: 5.28E-17mmHg at 25°C
• Refractive Index: 1.658
• PKA: 9.63±0.10(Predicted)
• CAS DataBase Reference: bis(4-hydroxyphenyl)(2-(phenoxysulfonyl)phenyl)methane(CAS DataBase Reference)
• NIST Chemistry Reference: bis(4-hydroxyphenyl)(2-(phenoxysulfonyl)phenyl)methane(115481-73-7)
• EPA Substance Registry System: bis(4-hydroxyphenyl)(2-(phenoxysulfonyl)phenyl)methane(115481-73-7)

Safety Data

• Hazardous Substances Data: 115481-73-7(Hazardous Substances Data)

Usage

InChI:InChI=1/C25H20O5S/c26-20-14-10-18(11-15-20)25(19-12-16-21(27)17-13-19)23-8-4-5-9-24(23)31(28,29)30-22-6-2-1-3-7-22/h1-17,25-27H

Upstream product

• 115511-92-7 bis(4.acetoxyphenyl)<2-(phenoxysulfonyl)phenyl>methane 
• 115481-76-0 2-[(4-Hydroxy-phenyl)-(4-oxo-cyclohexa-2,5-dienylidene)-methyl]-benzenesulfonic acid phenyl ester 
• 172464-36-7 2-(4,4'-dihydroxy-benzhydryl)-benzenesulfonic acid 
• 108-95-2 phenol 
• 115481-75-9 pyridinium 2-benzenesulfonate 
• 147510-56-3 Acetic acid 4-[(4-acetoxy-phenyl)-(2-chlorosulfonyl-phenyl)-methyl]-phenyl ester 
• 34487-61-1 phenolsulphophthaleine sodium salt 

Relevant articles and documents

Bis(4-hydroxyphenyl)methane: Isolation and Structure Elucidation of a Novel Estrogen from Commercial Preparations of Phenol Red (Phenolsulfonphthalein)

Commercial preparations of phenolsulfonphthalein (Phenol Red), a pH indicator dye widely added to cell culture media, have weak estrogenic activity that can be accounted for by a minor lipophilic impurity (ca. 0.002percent).We have isolated this impurity, determined its structure to be bis(4-hydroxyphenyl)methane, and synthesized it from phenolsulfonphthalein.This compound binds to the estrogen receptor with an affinity 50percent that of estradiol; it stimulates the proliferation and increases the progesterone receptor content of estrogen-responsive breast cancer cells in vitro, and stimulates uterine weight gain in rats in vivo, but shows a potency in these assays only 0.1-0.2percent that of estradiol.We suggest haw this novel estrogen may be generated during the preparation of phenolsulfonphthalein.