1155010-93-7Relevant academic research and scientific papers
Regioselective N-Addition/Substitution Reaction of α-Alkylidene Pyrazolinones with Propargyl Sulfonium Salts to Construct Allylthio-Containing Pyrazolones
Shen, Shou-Jie,Du, Xiao-Li,Xu, Xiao-Li,Zhao, Ming-Gang,Liang, Jin-Yan
, p. 12520 - 12531 (2019)
The regioselective N-addition/substitution reaction between α-alkylidene pyrazolinones and propargyl sulfonium salts has been developed to construct functionalized allylthio-containing pyrazolones with moderate to excellent yields. α-Alkylidene pyrazolinones act as N-nucleophilic agents which are distinguished from reported C-nucleophilic reactions. Excellent regioselectivity, readily available starting materials, the broad range of substrates, gram-scale synthesis, and simple operation illustrate the synthetic advantages of this new reaction pathway.
Asymmetric synthesis of atropisomeric pyrazole: Via an enantioselective reaction of azonaphthalene with pyrazolone
Yuan, Huijun,Li, Yao,Zhao, Hanhui,Yang, Zhihong,Li, Xin,Li, Wenjun
supporting information, p. 12715 - 12718 (2019/10/28)
The first catalytic asymmetric reaction of azonaphthalene with pyrazolone has been established. A wide range of axially chiral pyrazole derivatives have been achieved in good yields (68-99%) with excellent enantioselectivities (83-98% ee) by utilizing chiral phosphoric acid as a catalyst. This strategy provides an efficient and facile approach for the construction of axially chiral pyrazole derivatives. Theoretical calculations were carried out to elucidate the origins of enantioselectivity.
Asymmetric [3 + 3] Annulation of Copper-Allenylidenes with Pyrazolones: Synthesis of Chiral 1,4-Dihydropyrano[2,3- c]pyrazoles
Jiang, Feng,Feng, Xinping,Wang, Rou,Gao, Xing,Jia, Hao,Xiao, Yumei,Zhang, Cheng,Guo, Hongchao
supporting information, p. 5278 - 5281 (2018/09/13)
The copper-catalyzed asymmetric [3 + 3] annulation of ethynyl benzoxazinanones with pyrazolones has been achieved, providing simple access to 1,4-dihydropyrano[2,3-c]pyrazole derivatives in moderate to excellent yields with excellent enantioselectivities (up to 99% ee). Compared with previous annulation reactions of copper-allenylidenes from ethynyl benzoxazinanones, the current reaction fused the three carbon atoms of the propargyl moiety into a heterocyclic framework.
