115509-58-5

Upstream product

• 616-02-4 citraconic acid anhydride 
• 95106-90-4 3a,4-trans-3a,9a-cis-3a-Methyl-6,7-methylenedioxy-4-(3',4'-5'-trimethoxyphenyl)-3a,4,9,9a-tetrahydronaphtho<2,3-c>furan-1,3-dione 
• 115425-02-0 (5R,6R,7R)-6-Methyl-5-(3,4,5-trimethoxy-phenyl)-5,6,7,8-tetrahydro-naphtho[2,3-d][1,3]dioxole-6,7-dicarboxylic acid 7-isopropyl ester 
• 82792-81-2 1-(3,4,5-trimethoxyphenyl)-5,6-methylenedioxy-1,3-dihydrobenzothiophene-2,2-dioxide 
• 1026470-10-9 5-<1-Acetoxy-1-(3',4',5'-trimethoxyphenyl)methyl>-6-trimethylsilylmethyl-1,3-benzodioxole 
• 98151-84-9 5-<1-Hydroxy-1-(3',4',5'-trimethoxyphenyl)methyl>-6-trimethylsilylmethyl-1,3-benzodioxole 
• 98151-83-8 5-Bromo-6-trimethylsilylmethyl-1,3-benzodioxole 
• 98151-82-7 <(3,4-methylenedioxyphenyl)methyl>trimethylsilane 
• 495-76-1 piperonol 
• 2606-51-1 3,4-Methylenedioxybenzyl bromide 

Relevant academic research and scientific papers

The synthesis of structural analogues of the Podophyllum lignans: Selective Wittig reactions on 1-aryl-2-methyl-tetrahydronaphthoic acid anhydride

The title anhydride reacts with stabilised phosphorus ylids exclusively at the carbonyl remote from the 1-aryl substituent. These products have been converted into a variety of compounds related in structure to deoxyisopicrophyllotoxin.

A Practical Synthesis of the Anti-tumour Agent 2-Methyl-4-deoxyisopicropodophyllotoxin and Related Podophyllin Analogues

We describe an efficient, six-stage synthesis of 2-methyl-4-deoxyisopicropodophyllotoxin, which proceeds via a Diels-Alder cycloaddition between 2-methylmaleic anhydride and the orthoquinodimethane generated by treatment of 5-1-acetoxy-1-(3',4',5'-trimet