1155414-02-0Relevant articles and documents
5-(4-Hydroxyphenyl)-3H-1,2-dithiole-3-thione-based fibrates as potential hypolipidemic and hepatoprotective agents
Chen, Zi-Zhang,Xie, Yun-Dong,Shao, Li-Hua,Wang, Qiu-Tang,Xu, Yan-Hong,Bian, Xiao-Li
, p. 3787 - 3792 (2018)
Hypolipidemic effects of the newly synthesized 5-(4-hydroxyphenyl)-3H-1,2-dithiole-3-thione-based fibrates were evaluated in Triton WR-1339 and high-fat diet (HFD)-induced hyperlipidemic mice. Preliminary screening of all the synthesized compounds was don
New aryldithiolethione derivatives as potent histone deacetylase inhibitors
Tazzari, Valerio,Cappelletti, Graziella,Casagrande, Manolo,Perrino, Elena,Renzi, Luigi,Del Soldato, Piero,Sparatore, Anna
experimental part, p. 4187 - 4194 (2010/09/12)
A series of dithiolethione derivatives was synthesized and the in vitro HDAC inhibitory activity was tested. The most active compounds, 1 and 2, exhibited an IC50 in nM range with a strong hyperacetylation of histone H4 in A549 cells. The HDAC