115545-69-2

Upstream product

• 118534-84-2 Boc-Asp(O-2-Ada)-Gly-OBzl 
• 700-57-2 1-adamantanol 
• 115545-73-8 Boc-Asp-(O-2-Ada)-OSu 
• 118534-76-2 Boc-Asp(O-2-Ada)-OBzl 
• 115545-58-9 Boc-Asp(O-2-Ada)-OH 

Downstream Products

• 115545-70-5 Boc-Glu(OBzl)-Asp(O-2-Ada)-Gly-OBzl 
• 115545-72-7 Z-Glp-Glu(OBzl)-Asp(O-2-Ada)-Gly-OBzl 
• 115545-71-6 (S)-4-[(S)-2-(Adamantan-2-yloxycarbonyl)-1-(benzyloxycarbonylmethyl-carbamoyl)-ethylcarbamoyl]-4-amino-butyric acid benzyl ester 
• 91856-42-7 H-Glp-Glu-Asp-Gly-OH 

Relevant academic research and scientific papers

Amino Acids and Peptides. Part 19. Synthesis of β-1-and β-2-Adamantyl Aspartates and their Evaluation for Peptide Synthesis

β-1-and β-2-Adamantyl aspartates have been synthesized and their properties examined.Altough the 1-Ada group is labile to TFA, the 2-Ada group is unaffected during TFA treatment, but easily removable by methanesulphonic acid (MSA) at room temperature within 5 min.Both groups are unaffected by treatment with 55percent piperidine under conditions which easily cleave the fluoren-9-ylmethoxycarbonyl (Fmoc) group from α-amino group.Both groups can suppress aspartimide formation as a side reaction under acidic and basic conditions during the synthesis of aspartyl peptides. β-1-or β-2-Adamantyl aspartates may be applicable to solid-phase peptide synthesis in combination with Fmoc or Boc as an Nα-protecting group, respectively.Some properties of the aspartimide moiety are described.