91856-42-7

Basic information

• Product Name: pyroglutamyl-glutamyl-asparaginyl-glycine
• Synonyms: pyroglutamyl-glutamyl-asparaginyl-glycine
• CAS NO: 91856-42-7
• Molecular Formula: C16H22 N4 O10
• Molecular Weight: 430.37
• Mol File: 91856-42-7.mol

Chemical Properties

• Boiling Point: 1121.2°Cat760mmHg
• Flash Point: 631.9°C
• Appearance: /
• Density: 1.521g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.57
• PKA: 3.16±0.10(Predicted)
• CAS DataBase Reference: pyroglutamyl-glutamyl-asparaginyl-glycine(CAS DataBase Reference)
• NIST Chemistry Reference: pyroglutamyl-glutamyl-asparaginyl-glycine(91856-42-7)
• EPA Substance Registry System: pyroglutamyl-glutamyl-asparaginyl-glycine(91856-42-7)

Safety Data

• Hazardous Substances Data: 91856-42-7(Hazardous Substances Data)

Usage

InChI:InChI=1/C16H22N4O10/c21-10-3-1-7(18-10)15(29)19-8(2-4-11(22)23)16(30)20-9(5-12(24)25)14(28)17-6-13(26)27/h7-9H,1-6H2,(H,17,28)(H,18,21)(H,19,29)(H,20,30)(H,22,23)(H,24,25)(H,26,27)/t7-,8-,9-/m0/s1

Upstream product

• 115545-70-5 Boc-Glu(OBzl)-Asp(O-2-Ada)-Gly-OBzl 
• 115545-66-9 Z-Glp-Glu(OBzl)-NHNHBoc 
• 115545-71-6 (S)-4-[(S)-2-(Adamantan-2-yloxycarbonyl)-1-(benzyloxycarbonylmethyl-carbamoyl)-ethylcarbamoyl]-4-amino-butyric acid benzyl ester 
• 49761-41-3 Z-Glp-Glu(OBzl)-OH 
• 115545-64-7 Boc-Asp(O-1-Ada)-Gly-OBzl 
• 118534-84-2 Boc-Asp(O-2-Ada)-Gly-OBzl 
• 115545-69-2 H-Asp(O-2-Ada)-Gly-OBzl 
• 40291-26-7 N-benzyloxycarbonyl-L-pyroglutamic acid N-hydroxysuccinimido ester 
• 115545-65-8 H-Asp-Gly-OBzl 
• 1676-73-9 L-glutamic acid γ-benzyl ester 
• 115545-72-7 Z-Glp-Glu(OBzl)-Asp(O-2-Ada)-Gly-OBzl 
• 115545-67-0 Z-Glp-Glu(OBzl)-Asp-Gly-OBzl 

Relevant articles and documents

Amino Acids and Peptides. Part 19. Synthesis of β-1-and β-2-Adamantyl Aspartates and their Evaluation for Peptide Synthesis

β-1-and β-2-Adamantyl aspartates have been synthesized and their properties examined.Altough the 1-Ada group is labile to TFA, the 2-Ada group is unaffected during TFA treatment, but easily removable by methanesulphonic acid (MSA) at room temperature within 5 min.Both groups are unaffected by treatment with 55percent piperidine under conditions which easily cleave the fluoren-9-ylmethoxycarbonyl (Fmoc) group from α-amino group.Both groups can suppress aspartimide formation as a side reaction under acidic and basic conditions during the synthesis of aspartyl peptides. β-1-or β-2-Adamantyl aspartates may be applicable to solid-phase peptide synthesis in combination with Fmoc or Boc as an Nα-protecting group, respectively.Some properties of the aspartimide moiety are described.