115545-77-2Relevant academic research and scientific papers
AMINO ACID DERIVATIVES THAT STABILIZE SECONDARY STRUCTURES OF POLYPEPTIDES-IV. PRACTICAL SYNTHESIS OF 4-ALKYLAMINO-3-CYANO-6-AZABICYCLOOCT-3-ENES (BEN DERIVATIVES) AS γ-TURN TEMPLATES
Kemp, D.S.,Carter, Jeffery S.
, p. 4645 - 4648 (1987)
Ben derivatives have been prepared in five steps from 4-hydroxyproline by Barton cyanoethylation, ring closure, and derivitization.Proof of absolute configuration and practical synthesis of pure Ben enantiomers are described.
