AMINO ACID DERIVATIVES THAT STABILIZE SECONDARY STRUCTURES OF POLYPEPTIDES-IV. PRACTICAL SYNTHESIS OF 4-ALKYLAMINO-3-CYANO-6-AZABICYCLOOCT-3-ENES (BEN DERIVATIVES) AS γ-TURN TEMPLATES

DOI: 10.1016/S0040-4039(00)96586-9

Source and publish data:

Tetrahedron Letters p. 4645 - 4648 (1987)

Update date:2022-08-03

Topics:

Authors:

Kemp, D.S.

Carter, Jeffery S.

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Article abstract of DOI:10.1016/S0040-4039(00)96586-9

Ben derivatives have been prepared in five steps from 4-hydroxyproline by Barton cyanoethylation, ring closure, and derivitization.Proof of absolute configuration and practical synthesis of pure Ben enantiomers are described.

Full text of DOI:10.1016/S0040-4039(00)96586-9

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