AMINO ACID DERIVATIVES THAT STABILIZE SECONDARY STRUCTURES OF POLYPEPTIDES-IV. PRACTICAL SYNTHESIS OF 4-ALKYLAMINO-3-CYANO-6-AZABICYCLOOCT-3-ENES (BEN DERIVATIVES) AS γ-TURN TEMPLATES

DOI: 10.1016/S0040-4039(00)96586-9

Source and publish data:

Tetrahedron Letters p. 4645 - 4648 (1987)

Update date:2022-08-03

Topics:

Authors:

Kemp, D.S.

Carter, Jeffery S.

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1016/S0040-4039(00)96586-9

Ben derivatives have been prepared in five steps from 4-hydroxyproline by Barton cyanoethylation, ring closure, and derivitization.Proof of absolute configuration and practical synthesis of pure Ben enantiomers are described.

Full text of DOI:10.1016/S0040-4039(00)96586-9

Products guided by the article

Product name:(1S,5S)-3-Cyano-4-methoxy-6-aza-bicyclo[3.2.1]oct-3-ene-6-carboxylic acid benzyl ester

Cas No:115545-77-2

R&D Labs maybe for 115545-77-2

Zhaodu Fine Chemical Plant

Contact:86-310-8067016

Address:East Fuhua Road,Tiexi Chemical Industrial Estate,Hebei,China
JiYi Chemical (Beijing) Co., Ltd.

Contact:+86-10-89385733

Address:Shilou Town of Fangshan District， Beijing
Chengdu Sino-Strong Pharmaceutical Co.,Ltd.

website:http://www.sino-strong.com.cn

Contact:+86-28-82666753

Address:459 West haike road,Cross-straits technological industry park, Wenjiang district,Chengdu, P.R.China
Jinhua Haoyuan Chemical CO., LTD(expird)

Contact:86-579-82465583

Address:Jinhua,Zhejiang
Nanjing Duly Biotech Co., Ltd

website:http://www.dulynet.com/

Contact:025-84699383 -8003

Address:Room 503, Building 2, Chuangxinhui, No. 61 Wenjing Road, High-tech Development Zone, Pukou District, Nanjing City, Jiangsu Province Nanjing, Jiangsu

Relevant to this article

The total synthesis of argiopine (argiotoxin-636)

Doi:10.1016/S0040-4039(00)96851-5
(1987)
A facile and versatile synthesis of 2-substituted tryptophans as N(α)-tert-butyloxycarbonyl derivatives

Doi:10.1055/s-1988-27471
(1988)
Facile Displacement of an η⁵-Indenyl Ligand. Crystal Structure of the ⁺ Salt of the Naked Indenyl Anion

Doi:10.1039/c39870001478
(1987)
Arene ruthenium metallacycles containing chelating thioamide ligands

Doi:10.1016/j.jorganchem.2008.12.015
(2009)
Substituted metal carbonyls III. Chromium, molybdenum and tungsten tricarbonyl complexes containing bipyridyl and a unidentate diphosphine: facile synthesis via trimethylamine N-oxide-induced decarbonylations

Doi:10.1016/S0022-328X(00)98910-1
(1987)
cis, trans - Or both: Steric bulk determines coordination mode of dimeric palladium complexes with bridging pyridine-phosphane ligands

Doi:10.1002/ejic.200800804
(2008)

Article Doi