1155573-56-0

Basic information

• Product Name: 3-methyl-1-(2-bromophenyl)-1H-pyrazol-5-amine
• Synonyms: 3-methyl-1-(2-bromophenyl)-1H-pyrazol-5-amine
• CAS NO: 1155573-56-0
• Molecular Formula: C₁₀H₁₀BrN₃
• Molecular Weight: 252.1105
• Mol File: 1155573-56-0.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 386.7±32.0 °C(Predicted)
• Appearance: /
• Density: 1.57±0.1 g/cm3(Predicted)
• PKA: 3.41±0.10(Predicted)
• CAS DataBase Reference: 3-methyl-1-(2-bromophenyl)-1H-pyrazol-5-amine(CAS DataBase Reference)
• NIST Chemistry Reference: 3-methyl-1-(2-bromophenyl)-1H-pyrazol-5-amine(1155573-56-0)
• EPA Substance Registry System: 3-methyl-1-(2-bromophenyl)-1H-pyrazol-5-amine(1155573-56-0)

Safety Data

• Hazardous Substances Data: 1155573-56-0(Hazardous Substances Data)

Usage

Structure

Contains a pyrazole ring substituted with a methyl group (3-methyl), a bromophenyl group (2-bromophenyl), and an amino group (5-amine)

Application

Used in medicinal chemistry research and drug development

Biological Activities

Studied for its antifungal and anti-inflammatory properties

Potential for Cancer Treatment

Investigated as a candidate for cancer treatment

Scaffold for Drug Design

Shows potential as a scaffold for designing new drugs with therapeutic applications

Versatility

Offers diverse potential uses in pharmaceutical research.

Upstream product

• 1118-61-2 3-Aminocrotononitrile 
• 615-36-1 2-bromoaniline 
• 2469-99-0 Cyanoaceton 
• 16732-66-4 2-bromophenylhydrazine 

Downstream Products

• 1380573-50-1 4-(4-phenoxyphenyl)-3,6-dimethyl-1-(2-bromophenyl)-4,8-dihydro-1H-pyrazolo[3,4-e][1,4]thiazepin-7-one 

Relevant articles and documents

Metal-free ring opening of 5-amino-1,4-diaryl-1H-pyrazoles: A facile access to 2-aryl-3-arylazoacrylonitriles

Various 2-aryl-3-arylazoacrylonitriles are synthesized while attempting the intramolecular N-arylation of 5-aminopyrazoles, using the hypervalent iodine reagent. The synthesis involves phenyl iodine diacetate-assisted ring opening of 5-aminopyrazoles at r

Pyrazole[3,4-e][1,4]thiazepin-7-one derivatives as a novel class of Farnesoid X Receptor (FXR) agonists

A virtual screening procedure was applied to the discovery of structurally diverse non-steroidal Farnesoid X Receptor (FXR) agonists. From 117 compounds selected by virtual screening, a total of 47 compounds were found to be FXR agonists, with 34 of them showing activity below a concentration of 20 μM. 1H-Pyrazole[3,4-e][1,4]thiazepin-7-one-based hit compound 7 was chosen for hit-to-lead optimization. A large number of 1H-pyrazole[3,4-e][1,4]thiazepin-7- one derivatives was designed, synthesized, and evaluated by a cell-based luciferase transactivation assay for their agonistic activity against FXR. Most of them exhibited low micromolar range of potency and very high efficacy.