115563-09-2Relevant academic research and scientific papers
(E)-4-Lithio-4-tosylbutenone Dimethyl Ketal: A New and Versatile β-Acylvinyl Anion Equivalent in Organic Synthesis
Najera, Carmen,Yus, Miguel
, p. 4708 - 4715 (2007/10/02)
The lithiation of (E)-4-tosylbutenone dimethyl ketal (12) with methyllithium at -20 deg C led to the new β-acylvinyl anion equivalent (E)-4-lithio-4-tosylbutenone dimethyl ketal (13).The treatment of intermediate 13 with different electrophilic reagents (
(E)-4-LITHIO-4-TOSYLBUTENONE DIMETHYL KETAL: A NEW β-ACYLVINYL ANION EQUIVALENT
Najera, Carmen,Yus, Miguel
, p. 6709 - 6712 (2007/10/02)
(E)-4-Lithio-4-tosylbutenone dimethyl ketal is regio and stereoselectively prepared by direct lithiation of the corresponding precursor with methyl-lithium at -20 deg C; the reaction of this β-acylvinyl anion equivalent with different electrophilic reagents (H2O, D2O, Me3SiCl, Me2S2, MeI, CH2=CHCH2Br, BuiCHO, PhCHO, PhCOCl, Ac2O) affords the corresponding functionalized compounds.
