1155705-57-9Relevant academic research and scientific papers
Reverse fosmidomycin derivatives against the antimalarial drug target IspC (Dxr)
Behrendt, Christoph T.,Kunfermann, Andrea,Illarionova, Victoria,Matheeussen, An,Pein, Miriam K.,Gr?wert, Tobias,Kaiser, Johannes,Bacher, Adelbert,Eisenreich, Wolfgang,Illarionov, Boris,Fischer, Markus,Maes, Louis,Groll, Michael,Kurz, Thomas
, p. 6796 - 6802 (2011/12/04)
Reverse hydroxamate-based inhibitors of IspC, a key enzyme of the non-mevalonate pathway of isoprenoid biosynthesis and a validated antimalarial target, were synthesized and biologically evaluated. The binding mode of one derivative in complex with EcIspC
Synthesis and antiplasmodial activity of highly active reverse analogues of the antimalarial drug candidate fosmidomycin
Behrendt, Christoph T.,Kunfermann, Andrea,Illarionova, Victoria,Matheeussen, An,Graewert, Tobias,Groll, Michael,Rohdich, Felix,Bacher, Adelbert,Eisenreich, Wolfgang,Fischer, Markus,Maes, Louis,Kurz, Thomas
, p. 1673 - 1676 (2011/12/21)
Inhibition of enzymes involved in the nonmevalonate pathway of isoprenoid biosynthesis represents a promising strategy for the development of novel antimalarial agents. A small series of reverse hydroxamate-based fosmidomycin analogues was synthesized and evaluated for their inhibitory activity against the recombinant 1-deoxy-D-xylulose 5-phosphate reductoisomerases (DXRs) of Escherichia coli and Plasmodium falciparum, as well as for their in vitro antiplasmodial activity and cytotoxicity.
Rhodium-catalyzed highly regioselective hydroformylation-hydrogenation of 1,2-allenyl-phosphine oxides and -phosphonates
Guo, Hao,Ma, Shengming
supporting information; experimental part, p. 1213 - 1217 (2009/05/30)
The rhodium-catalyzed hydroformylation-hydrogenation of 1,2-allenyl-phosphine oxides and -phosphonates is reported in this paper. The regio-selectivity was well controlled, affording only saturated linear γ-phosphinyl aldehydes under the standard conditio
