115572-70-8Relevant articles and documents
Stereoselective Alkylation of Glycine Units in Dipeptide Derivatives: "Chirality Transfer" via a Pivalaldehyde N,N-Acetal Center
Polt, Robin,Seebach, Dieter
, p. 2622 - 2632 (2007/10/02)
Dipeptide esters (of glycylglycine, glycylalanine, alanylglycine) and aldehydes (isobutyraldehyde, pivalaldehyde, benzaldehyde) are condensed to (4-oxoimidazolidin-3-yl)acetates and -propionates (1-3).Lithium enolates of these derivatives, are generated (
178. Alkylation of Imidazolidinone Dipeptide Derivatives: Preparation of Enantiomerically Pure Di- and Tripeptides by "Chirality Transfer" via a Pivalaldehyde N,N-Acetal Center
Polt, Robin,Seebach, Dieter
, p. 1930 - 1936 (2007/10/02)
Glycylglycine, glycyl-(S)-alanine, and (S)-alanylglycine esters are cyclized through pivalaldehyde imines to give dipeptide-derived 3-(benzyloxycarbonyl)-2-(tert-butyl)-5-oxoimidazolidine-1-acetates 1-3.These are alkylated diastereoselecively by Li-enolat