1155843-52-9

Basic information

• Product Name: N-[(9R)-6'-methoxycinchonan-9-yl]-N'-[tris(3,5-dimethylphenyl)methyl]thiourea
• CAS NO: 1155843-52-9
• Molecular Weight: 709.011
• Mol File: 1155843-52-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: N-[(9R)-6'-methoxycinchonan-9-yl]-N'-[tris(3,5-dimethylphenyl)methyl]thiourea(CAS DataBase Reference)
• NIST Chemistry Reference: N-[(9R)-6'-methoxycinchonan-9-yl]-N'-[tris(3,5-dimethylphenyl)methyl]thiourea(1155843-52-9)
• EPA Substance Registry System: N-[(9R)-6'-methoxycinchonan-9-yl]-N'-[tris(3,5-dimethylphenyl)methyl]thiourea(1155843-52-9)

Safety Data

• Hazardous Substances Data: 1155843-52-9(Hazardous Substances Data)

Upstream product

• 1155843-59-6 tris(3,5-dimethylphenyl)methyl isothiocyanate 
• 287979-82-2 9-amino-9-deoxyepiquinidine 

Relevant articles and documents

A simple organocatalytic enantioselective synthesis of pregabalin

This paper describes a new procedure for the enantioselective synthesis of the important anticonvulsant drug Pregabalin, which shows biological properties as the (S) enantiomer only. The key step of the synthetic sequence is the Michael addition reaction of Meldrum's acid to a nitroalkene mediated by a quinidine derived thiourea. A variety of novel catalysts bearing different groups at the thiourea moiety were synthesized and tested. The most successful catalyst that incorporates a trityl substituent provided up to 75 % ee of (S)- 4. The conjugate addition reaction was carried out on a multigram scale with low loadings of catalyst (10 mol-%). Moreover, the catalyst can be recycled showing the same capability in chemical yield and asymmetric induction. Then, hydrogenation of nitroalkane 4 followed by decarboxylation of diacid 5 provides Pregabalin hydrochloride in 59% overall yield. Enantioenrichment by crystallization of the free amino acid 1 improves the (S)/(R) enantiomeric ratio to 9:1. ? Wiley-VCII Verlag GmbH & Co. KGaA.