1155860-72-2Relevant academic research and scientific papers
POTENT NON-UREA INHIBITORS OF SOLUBLE EPOXIDE HYDROLASE
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, (2016/08/03)
The present invention relates to compounds that exhibit vasodilatory and anti-inflammatory effects by inhibiting the activity of soluble epoxide hydrolase (sEH). The present invention is also directed to methods of identifying such compounds, and use of s
Discovery of potent non-urea inhibitors of soluble epoxide hydrolase
Xie, Yuli,Liu, Yidong,Gong, Gangli,Smith, Deborah H.,Yan, Fang,Rinderspacher, Alison,Feng, Yan,Zhu, Zhengxiang,Li, Xiangpo,Deng, Shi-Xian,Branden, Lars,Vidovic, Dusica,Chung, Caty,Schuerer, Stephan,Morisseau, Christophe,Hammock, Bruce D.,Landry, Donald W.
scheme or table, p. 2354 - 2359 (2009/12/07)
Soluble epoxide hydrolase (sEH) is a novel target for the treatment of hypertension and vascular inflammation. A new class of potent non-urea sEH inhibitors was identified via high throughput screening (HTS) and chemical modification. IC50s of the most potent compounds range from micromolar to low nanomolar.
