1156429-84-3Relevant academic research and scientific papers
Unsaturated oxazolones as nonlinear fluorophores
Rodrigues, Catarina A.B.,Mariz, Inês F.A.,Ma??as, Ermelinda M.S.,Afonso, Carlos A.M.,Martinho, José M.G.
, p. 642 - 652 (2013)
Unwanted bleaching of two-photon absorption microscopy probes can be reduced by designing more efficient nonlinear fluorophores. Here the linear and nonlinear photophysical properties of unsaturated oxazolones are studied. A set of push-pull oxazolone der
Acetic Acid Accelerated Visible-Light Photoredox Catalyzed N-Demethylation of N,N-Dimethylaminophenyl Derivatives
Wu, Guolin,Li, Yazhen,Yu, Xuemei,Gao, Yu,Chen, Haijun
, p. 687 - 692 (2017/02/23)
N,N-Dimethylaminophenyl moiety is a common fragment in medicinal chemistry as several pharmaceuticals bearing this privileged motif are on the market and under clinical evaluation. Oxidative N-demethylation is generally regarded as the major metabolic pathway. However, pharmacokinetics, metabolites studies as well as the further structural modification are precluded by the impracticality of chemical synthesis. Here we report that acetic acid can significantly accelerate visible-light photoredox catalyzed N-demethylation of N,N-dimethylaminophenyl derivatives. This approach is easy for large scale reaction and even for potential industrial manufacture. (Figure presented.).
