5680-79-5Relevant articles and documents
Synthesis of N-(imidomethyl)glycine esters from alkyl glycinates, imides of dicarboxylic acids, and formaldehyde
Zlotin, S. G.,Sharova, I. V.,Luk'yanov, O. A.
, p. 1260 - 1261 (1995)
A method for preparing N-(imidomethyl)glycine esters by the reaction of alkyl glycinates with formaldehyde and imides has been developed. - Keywords: alkyl glycinates; formaldehyde; imides; Mannich base.
Glycine modified graphene oxide as a novel sorbent for preconcentration of chromium, copper, and zinc ions from water samples prior to energy dispersive X-ray fluorescence spectrometric determination
Pytlakowska, Katarzyna,Kozik, Violetta,Matussek, Marek,Pilch, Micha?,Hachu?a, Barbara,Kocot, Karina
, p. 42836 - 42844 (2016)
A novel and selective sorbent for micro-solid phase extraction was synthesized by chemical functionalization of graphene oxide with glycine. The structure of this nanomaterial, referred to as GO-Gly, was confirmed by Fourier transform infrared spectroscopy, X-ray photoelectron spectroscopy, and scanning electron microscopy. GO-Gly was used for preconcentration of chromium, zinc, and copper ions from water samples prior to their determination by energy dispersive X-ray fluorescence spectrometry (EDXRF). The proposed procedure is based on dispersion of micro amounts of GO-Gly in aqueous samples. After adsorption of metal ions on its surface, samples were filtered under vacuum and then membrane filters were directly submitted to energy dispersive X-ray fluorescence spectrometric measurements. In order to obtain optimal preconcentration conditions, some parameters affecting sorption process, such as pH, amount of GO-Gly, sorption times, and sample volume, were examined. Under optimal conditions the calibration curves were linear in a 1-150 ng mL-1 range with recoveries higher than 97%. The obtained detection limits for Cr(iii), Zn(ii), and Cu(ii) determinations are 0.15, 0.07, and 0.08 ng mL-1, respectively. A relative standard deviation of the proposed procedure (at a 10 ng mL-1 level for n = 10) is lower than 2.3%. The proposed method was successfully applied for determination of Cr(iii), Zn(ii), and Cu(ii) ions in water samples.
Translation of Mycobacterium Survival Strategy to Develop a Lipo-peptide based Fusion Inhibitor**
Sardar, Avijit,Lahiri, Aritraa,Kamble, Mithila,Mallick, Amirul I.,Tarafdar, Pradip K.
supporting information, p. 6101 - 6106 (2021/02/01)
The entry of enveloped virus requires the fusion of viral and host cell membranes. An effective fusion inhibitor aiming at impeding such membrane fusion may emerge as a broad-spectrum antiviral agent against a wide range of viral infections. Mycobacterium survives inside the phagosome by inhibiting phagosome–lysosome fusion with the help of a coat protein coronin 1. Structural analysis of coronin 1 and other WD40-repeat protein suggest that the trp-asp (WD) sequence is placed at distorted β-meander motif (more exposed) in coronin 1. The unique structural feature of coronin 1 was explored to identify a simple lipo-peptide sequence (myr-WD), which effectively inhibits membrane fusion by modulating the interfacial order, water penetration, and surface potential. The mycobacterium inspired lipo-dipeptide was successfully tested to combat type 1 influenza virus (H1N1) and murine coronavirus infections as a potential broad-spectrum antiviral agent.
Silver-Mediated [3 + 2] Cycloaddition of Azomethine Ylides with Trifluoroacetimidoyl Chlorides for the Synthesis of 5-(Trifluoromethyl)imidazoles
Yang, Hefei,Lu, Shu-Ning,Chen, Zhengkai,Wu, Xiao-Feng
supporting information, p. 4361 - 4370 (2021/03/09)
A silver-mediated [3 + 2] cycloaddition of azomethine ylides with trifluoroacetimidoyl chlorides for the rapid assembly of 5-(trifluoromethyl)imidazoles has been developed. Notable features of the reaction include readily accessible reagents, a broad substrate scope, and high efficiency. The protocol can be successfully applied to construct the analogue of the specific allosteric modulator of GABAA receptors. The silver species could be recycled by a simple operation.
