115664-86-3

Upstream product

• 2555-29-5 8-acetyl-7-hydroxy-4-methyl-2H-chromen-2-one 
• 123-11-5 4-methoxy-benzaldehyde 
• 66262-40-6 7-methoxy-4-methyl-8-coumarinyl methyl ketone 
• 90-33-5 7-hydroxy-4-methyl-chromen-2-one 
• 2747-05-9 4-methylumbelliferyl acetate 
• 108-46-3 recorcinol 
• 116589-48-1 7-Methoxy-8-[(E)-3-(4-methoxy-phenyl)-acryloyl]-4-methyl-chromen-2-one 

Downstream Products

• 115664-95-4 ethyl <8-(4-methoxycinnamoyl)-4-methyl-2-oxo-2H-1-benzopyranyl-7-oxy>acetate 
• 115664-89-6 3-(7-Hydroxy-4-methyl-2-oxo-2H-chromen-8-yl)-5-(4-methoxy-phenyl)-4,5-dihydro-pyrazole-1-carbaldehyde 
• 115665-01-5 ethyl <8-(1-acetyl-4,5-dihydro-5-(4-methoxyphenyl)-3-pyrazolyl)-4-methyl-2-oxo-2H-1-benzopyranyl-7-oxy>acetate 
• 115664-98-7 {8-[1-Formyl-5-(4-methoxy-phenyl)-4,5-dihydro-1H-pyrazol-3-yl]-4-methyl-2-oxo-2H-chromen-7-yloxy}-acetic acid ethyl ester 
• 115665-03-7 8,9-dihydro-8-(4-methoxyphenyl)-4-methyl-2H,10H-benzo<1,2-b:3,4-b'>dipyran-2,10-dione 
• 116589-45-8 8-(α,β-dihydro-4'-methoxycinnamoyl)-7-hydroxy-4-methylcoumarin 

Relevant academic research and scientific papers

Coumarin moiety can enhance abilities of chalcones to inhibit DNA oxidation and to scavenge radicals

Coumarin and chalcone are naturally occurring compounds, and coumarin as a functional group was combined with chalcone in this work, aiming to test the inhibitory effects of coumarin-substituted chalcones on the oxidation of DNA and on scavenging radicals. It was found that the antioxidant activity of hydroxyl group attaching to coumarin can be increased by hydroxyl groups attaching to chalcone. The double hydroxyl groups at adjacent position exhibited high abilities to inhibit Cu2+/glutathione-induced oxidation of DNA and to trap 2,2′-azinobis(3-ethylbenzothiazoline-6-sulfonate) cationic radical (ABTS+) as well as 2,2′-diphenyl-1-picrylhydrazyl radical (DPPH). Especially, the double hydroxyl groups in chalcone were able to protect DNA against 2,2′-azobis(2-amidinopropanehydrochloride) (AAPH)-induced oxidation significantly. On the other hand, the hydroxyl group attaching to coumarin exhibited high ability to inhibit OH-induced oxidation of DNA. Therefore, coumarin-appended chalcones exhibited higher antioxidant effectiveness with only single or double phenolic hydroxyl groups contained.

Microwave-assisted synthesis of substituted 4-chloro-8-methyl-2-phenyl-1,5-dioxa-2H-phenanthren-6-ones and their antimicrobial activity

Chromene and coumarin scaffolds are known for their potential antimicrobial activity. Herein, we have synthesized hybrid compounds containing both, substituted 4-chloro-8-methyl-2-phenyl-1,5-dioxa-2H-phenanthren-6-ones, 3a-o have been synthesized from sub

Microwave-assisted synthesis of (E)-7-[(1-benzyl-1H-1,2,3-triazol-4-yl)methoxy]-8-(3-arylacryloyl)-4-methyl-2H-chromen-2-ones and their antimicrobial activity

Hybrid compounds are relevant products in the structure-activity relationships analysis. A new series of hybrid compounds containing coumarin, 1,2,3-triazole, and chalcone substructures were synthesized and screened for their antimicrobial activity. The s

Synthesis and antiproliferative and c-Src kinase inhibitory activities of cinnamoyl-and pyranochromen-2-one derivatives

A series of 6-and 8-cinnamoylchromen-2-one and dihydropyranochromen-2-one derivatives were synthesized and their antiproliferative activities were evaluated against three human cancer cell lines, i.e., ovarian adenocarcinoma (SK-OV-3), leukemia (CCRF-CEM), and breast carcinoma (MCF-7). In general, 8-cinnamoylchromen-2-one derivatives were found to have higher antiproliferative activity against the cancer cells when compared with 6-cinnamoyl analogues. Among all of the hybrid chromen-2-one-chalcone/flavanone compounds, a 7-hydroxy-8-cinnamoylchromen-2-one derivative 35 was found to be consistently active against all the cancer cell lines and inhibited the cell proliferation of SK-OV-3, CCRF-CEM, and MCF-7 by 63%, 50%, and 43%, respectively, at a concentration of 50 μmol/L after 72 h of incubation. This compound also exhibited the highest Src kinase inhibition (IC50 = 14.5 μmol/L). Structure-activity relationship studies provided insights for designing the next generation of chromen-2-one-chalcone hybrid prototypes and the development of new leads as anticancer agents and (or) Src kinase inhibitors.

Synthesis of some new 1,5-benzothiazepines containing 2H-1-benzopyran-2-one heterocycle

A facile procedure has been developed for the synthesis of 2-aryl/heteryl-4-(2H-1-benzopyran-2-one-8-yl)-2,3-dihydro-1,5-benzothiazepines (5a-o) by the reaction of 1-(2H-1-benzopyran-2-one-8-yl)-3-aryl/heteryl-2-propenones (3a-k) with 2-aminothiophenols (4a,b) in toluene in the presence of triflouroacetic acid.

Synthesis of new α-pyronochalcones and related cyclisation products

Ten substituted α-pyronochalcones (I-X) and four α-pyronoflavanones (XI-XIV) have been obtained from 8-acetyl-7-hydroxy-4-methylcoumrin and characterised.The present data cast serious doubts in the claim in a recent publication on the synthesis of benzopy

New Route to Synthesis of Some 8-(Dihydrocinnamoyl)dihydrocumarin Derivatives

The synthesis of 8-dihydrocinnamoyldihydrocoumarin derivatives starting from 8-acetyl-7-methoxy substituted coumarins involves: (i) aldol condensation with substituted benzaldehydes; (ii) partial demethylation of condensation products (AlCl3/acetonitrile)

Synthesis and Biological Properties of Substituted 2H-1-Benzopyran-2-ones and 2H,10H-Benzodipyran-2,10-diones

In continuation of our earlier studies in substituted pyrazoles, benzopyranopyrazoles, benzindazoles, benzcycloheptapyrazoles, pyrazoloquinolines and 2/4H-1-benzopyran-2/4-ones, which exhibit various biological activities, n