115665-66-2Relevant academic research and scientific papers
Mild and efficient method for decarboxylative bromination of α,β-unsaturated carboxylic acids with Dess-Martin periodinane
Telvekar, Vikas N.,Arote, Nitin D.,Herlekar, Omkar P.
, p. 2495 - 2497 (2005)
A simple and mild method for decarboxylative bromination of α,β-unsaturated carboxylic acids has been developed using Dess-Martin Periodinane (DMP) in combination with tetraethylammonium bromide (TEAB) at room temperature. High yields of the corresponding bromoalkenes were obtained. Georg Thieme Verlag Stuttgart.
A novel system for decarboxylative bromination
Telvekar, Vikas N.,Chettiar, Somsundaram N.
, p. 4529 - 4532 (2007)
A simple and mild method for decarboxylative bromination of α,β-unsaturated carboxylic acids has been developed using diphosphorus tetraiodide in combination with tetraethylammonium bromide (TEAB) at room temperature. High yields of the corresponding bromoalkenes were obtained.
Regio- and stereoselective synthesis of bromoalkenes by homolytic hydrobromination of alkynes with hydrogen bromide
Kinoshita, Hidenori,Kumaki, Wataru,Miura, Katsukiyo
, (2022/03/07)
Homolytic hydrobromination of terminal and internal alkynes with a commercially available solution of hydrogen bromide in acetic acid has been investigated for regio- and stereoselective synthesis of bromoalkenes. Under an aerobic atmosphere at room temperature, the reaction of ethynylarenes with a small excess of HBr efficiently gave (2-bromoethenyl)arenes with good to high E-selectivity. (Alk-1-ynyl)arenes, or internal alkynes bearing both phenyl and alkyl groups at the sp-carbons also underwent the air-initiated hydrobromination to exhibit high Z-selectivity under kinetic conditions using a half equivalent of HBr.
A Simplified Protocol for the Stereospecific Nickel-Catalyzed C-S Vinylation Using NiX 2 Salts and Alkyl Phosphites
Larin, Egor M.,Lautens, Mark,Marchese, Austin D.,Mirabi, Bijan
, p. 311 - 319 (2019/12/28)
A Ni-catalyzed C-S cross-coupling using only NiI 2 (0.5-2.5 molpercent) and P(O i Pr) 3 (2.0-10.0 molpercent) is reported. Using an air-stable Ni(II) precatalyst, and a cheap and commercially available ligand, a scalable and robust method was developed to cross-couple various thiophenols and styryl bromides, including some sterically encumbered thiols, an α-bromocinnamaldehyde as well as a thiolation-cyclization.
TsNBr2 promoted decarboxylative bromination of α,β-unsaturated carboxylic acids
Hazarika, Debojit,Phukan, Prodeep
supporting information, p. 4593 - 4596 (2018/11/23)
A rapid process for decarboxylative bromination of α,β-unsaturated carboxylic acids have been developed using N,N-dibromo-p-toluenesulfonamide (TsNBr2). Treatment of cinnamic acids with TsNBr2 in presence of potassium carbonate in acetonitrile produces corresponding β-bromostyrenes at room temperature. Exclusive formation of (E)-β-bromostyrenes was observed in a stereoselective manner within a very short period of time (5–15 min). This method was further extended for obtaining 1-bromoalkynes from corresponding propiolic acids. Instantaneous formation of bromoalkynes was observed when the reaction was carried out in presence of DBU as a base in acetonitrile at room temperature. A wide variety of cinnamic acids and propiolic acids could be converted to corresponding β-bromostyrenes and 1-bromoalkynes respectively under mild reaction condition with high to excellent yield.
FARNESOID X RECEPTOR AGONISTS AND USES THEREOF
-
, (2017/04/11)
Described herein are compounds that are farnesoid X receptor agonists, methods of making such compounds, pharmaceutical compositions and medicaments comprising such compounds, and methods of using such compounds in the treatment of conditions, diseases, or disorders associated with farnesoid X receptor activity.
H-β-zeolite catalyzed synthesis of β-bromostyrenes from styrene bromohydrins
Pappula, Venkatanarayana,Donthiri, Ramachandra Reddy,Darapaneni, Chandra Mohan,Subbarayappa, Adimurthy
supporting information, p. 1793 - 1795 (2014/03/21)
Synthesis of β-bromostyrenes from styrene bromohydrins using H-β-zeolite as catalyst under moderate conditions is reported. The catalyst could be regenerated and reused up to three consecutive cycles.
Decarboxylative bromination of cinnamic acids by 2-iodoxybenzoic acid with tetrabutylammonium bromide
Han, Jianlei,Wei, Yuping
experimental part, p. 247 - 248 (2012/09/22)
The decarboxylative bromination of cinnamic acids using the hypervalent iodine reagent 2-iodoxybenzoic acid with tetrabutylammonium bromide is described, providing good to excellent yields of bromostyrenes. Bromostyrenes are useful coupling components in a wide range of transition metal-catalysed coupling reactions.
A novel method for bromodecarboxylation of α,β-unsaturated carboxylic acids using catalytic sodium nitrite
Telvekar, Vikas N.,Takale, Balaram S.
experimental part, p. 2394 - 2396 (2011/05/09)
A first novel synthetic utility of catalytic sodium nitrite in combination with aqueous HBr, for bromo decarboxylation of α,β-unsaturated carboxylic acid is described. α,β-Unsaturated carboxylic acid compounds successfully converted into corresponding bromo compounds. The advantages of this protocol are shorter reaction time and moderate to good yields.
Microwave-assisted Pd/Cu-catalyzed C-8 direct alkenylation of purines and related azoles: An alternative access to 6,8,9-trisubstituted purines
Vabre, Roxane,Chevot, Franciane,Legraverend, Michel,Piguel, Sandrine
experimental part, p. 9542 - 9547 (2011/12/22)
An efficient microwave-assisted palladium/copper comediated C-8 direct alkenylation of purines with styryl bromides has been developed. The method is regioselective, functional group tolerant, rapid, and compatible with other related azoles. Combined with
