3034-94-4

Basic information

• Product Name: 3-NITROPHENYLACETYLENE
• Synonyms: 1-ETHYNYL-3-NITRO-BENZENE;3-NITROPHENYLACETYLENE;Benzene, 1-ethynyl-3-nitro- (6CI, 7CI, 8CI, 9CI);1-(3-Nitrophenyl)ethyne;1-Nitro-3-ethynylbenzene;3-NITROPHENL ACETYLENE
• CAS NO: 3034-94-4
• Molecular Formula: C₈H₅NO₂
• Molecular Weight: 147.13
• EINECS: 221-232-0
• Product Categories: pharmacetical
• Mol File: 3034-94-4.mol
• Article Data: 41

Chemical Properties

• Melting Point: 27 °C
• Boiling Point: 238.1 °C at 760 mmHg
• Flash Point: 105.9 °C
• Appearance: /
• Density: 1.22 g/cm³
• Vapor Pressure: 0.0664mmHg at 25°C
• Refractive Index: 1.579
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• CAS DataBase Reference: 3-NITROPHENYLACETYLENE(CAS DataBase Reference)
• NIST Chemistry Reference: 3-NITROPHENYLACETYLENE(3034-94-4)
• EPA Substance Registry System: 3-NITROPHENYLACETYLENE(3034-94-4)

Safety Data

• Hazardous Substances Data: 3034-94-4(Hazardous Substances Data)

Usage

General Description

3-Nitrophenylacetylene is a chemical compound primarily used in the field of organic chemistry as a building block in organic synthesis. 3-NITROPHENYLACETYLENE, which consists of a phenyl ring substituted with a nitro group and a triple bond at the para position, belongs to the nitro compounds and alkynes family. It has a molecular weight of approximately 193.16 g/mol and is known for its high reactivity due to the presence of the acetylene group, making it a key ingredient in the manufacture of pharmaceuticals, agrochemicals, and performance materials. Importantly, the handling and usage of 3-Nitrophenylacetylene require precautionary measures due to its potential health hazards.

InChI:InChI=1/C8H5NO2/c1-2-7-4-3-5-8(6-7)9(10)11/h1,3-6H

Upstream product

• 530-85-8 3-(2-nitrophenyl)-2-propynoic acid 
• 129972-90-3 3-(3-nitrophenyl)-1-phenylprop-2-yn-1-one 
• 113639-16-0 1-(3-Nitro-phenyl)-2-[1,3,3-trimethyl-1,3-dihydro-indol-(2E)-ylidene]-ethanone 
• 103606-71-9 3-(3-nitrophenyl)-2-propyn-1-ol 
• 33432-52-9 2-methyl-4-(3-nitrophenyl)-3-butyn-2-ol 
• 82594-66-9 (Z)-1-(2-bromo-vinyl)-3-nitro-benzene 
• 4996-15-0 3-(3-nitrophenyl)propynoic acid 
• 7732-18-5 water 
• 183322-33-0 1-nitro-3-[2-(trimethylsilyl)ethynyl]benzene 
• 18193-72-1 (2RS,3SR)-2,3-dibromo-3-(3-nitrophenyl)propanoic acid 
• 585-79-5 m-nitrobromobenzene 
• 555-68-0 (E)-3-Nitrocinnamic acid 
• 18193-72-1 2,3-dibromo-3-(3-nitro-phenyl)-propionic acid 
• 99-61-6 3-nitro-benzaldehyde 

Downstream Products

• 964-91-0 5-(3-nitrophenyl)-3-phenylisoxazole 
• 134682-50-1 1-(3-nitrophenyl)-2-(4-nitrophenyl)acetylene 
• 2765-15-3 1-nitro-3-[(3-nitrophenyl)ethynyl]benzene 
• 122540-43-6 3,3'-bis<β-(phenyltelluro)vinyl>azobenzene 
• 122540-45-8 4,4'-bis<β-(phenyltelluro)vinyl>azobenzene 
• 110296-08-7 (Z)-3-aminostyryl phenyl telluride 
• 42254-91-1 4,4'-divinylazobenzene 
• 1026570-81-9 1-((R)-1,2-Bis-trichlorosilanyl-ethyl)-3-nitro-benzene 
• 1008454-09-8 C₁₉H₁₅NO₄ 
• 53059-30-6 3'-nitro-[1,1'-biphenyl]-4-ol 
• 1392493-03-6 5-(3-nitrophenyl)-3-(phenylsulfonyl)-1H-pyrazole 
• 1355996-78-9 1-benzyl-4-(3-nitrophenyl)-1H-1,2,3-triazole 

Relevant articles and documents

A METHOD FOR THE PREPARATION OF TERMINAL ACETYLENES

A new pathway is proposed for the preparation of terminal acetylenes entailing the condensation of acid chlorides with phenylacetylene, isomerization of the acetylenic ketones with displacement of the oxo group and triple bond in the ketoacetylenic fragment, and subsequent alkaline cleavage of the isomerized ketones.

Preparation method of acetenyl aniline

The invention discloses a preparation method of acetenyl aniline, wherein the preparation method comprises the following steps: by using nitroethylbenzene as a raw material and MBr-MBrO3-H2SO4 (M=Na or K) as a bromination reagent, carrying out free radical bromination reaction to prepare 1,1-dibromo-1-(nitrophenyl)ethane, carrying out elimination reaction under the action of alkali to obtain nitrophenylacetylene, and finally, carrying out Fe/HCl reduction to obtain acetenyl aniline. The preparation method provided by the invention has the advantages of cheap and easily available raw materials, simple and safe operation, good reaction selectivity, high product yield, less emission of three wastes and the like.

Synthesis and application of novel triazole compound

The invention discloses a novel triazole compound as shown in figure 1 and an application of the novel triazole compound as a protein arginine methyltransferase 5 inhibitor, and discloses an application of the compound in prevention and/or treatment of cancer-related diseases caused by abnormal activity of protein arginine methyltransferase 5.