115705-35-6Relevant academic research and scientific papers
Coordination behavior of new bis(tridentate ONO, ONS and ONN) donor hydrazones towards some transition metal ions: Synthesis, spectral, thermal, antimicrobial and antitumor studies
Shebl, Magdy
, p. 79 - 93 (2017)
Three new hydrazone ligands, H2L1, H2L2 and H4L3, were prepared by condensation of 4,6-bis(1-hydrazonoethyl)benzene-1,3-diol with furan-2-carboxaldehyde, thiophene-2-carboxaldehyde and 1H-pyrrole-2-carboxaldehyde, respectively. The ligands reacted with copper(II), nickel(II), cobalt(II), zinc(II), cadmium(II) and dioxouranium(VI) ions to yield binuclear complexes formulated as [(L)M2(OAc)2(H2O)n(EtOH)m]·xH2O·yEtOH where L = L1 or L2; M = Cu, Ni, Co, Zn or Cd; n = nil, 1 or 4; m, x and y = nil or 1, [(H2L2)Cd2(OAc)4(H2O)2]·EtOH, [(L)(UO2)2(OAc)2(H2O)2Y2]·nH2O where L = L1 or L2; Y = nil or H2O; n = 2.5 or 7, [(L3)M2(H2O)6]·nH2O where M = Cu or Zn; n = 1 or 6, [(L3)(UO2)2(H2O)4]·2.5H2O and dimeric complexes; [(L1)2Ni2]·3H2O and [(H2L3)2M2]·nH2O where M = Ni or Co; n = 1.5 or 3. The ligands and their metal complexes were characterized by elemental analyses, IR, 1H and 13C NMR, electronic, ESR and mass spectra, conductivity, magnetic susceptibility measurements and powder XRD as well as thermal analysis. The coordinating sites are phenolic oxygens, azomethine nitrogens and the hetero O/N/S atoms. Octahedral, tetrahedral and square planar geometrical arrangements are proposed for metal complexes whilst the uranium ion is hepta- or octa-coordinated. The kinetics of the thermal decomposition for some metal complexes were studied and their thermodynamic parameters were calculated using Coats-Redfern method. The antimicrobial activity of the ligands and their complexes was screened. The antitumor activity of the ligands and their complexes was tested on Ehrlich Ascites Carcinoma. Copper(II) complexes showed promising IC50 values, which are comparable to that of cisplatin.
Benzodipyrazoles: Non-Xanthine Adenosine Antagonists
Peet, Norton P.,Dickerson, George A.,Abdallah, Abdulminium H.,Daly, John W.,Ukena, Dieter
, p. 2034 - 2039 (1988)
3,5-Dimethylbenzodipyrazoles, optionally substituted in the 1-, 7-, and 8-positions, were synthesized from resorcinols.These compounds display affinity for adenosine A1 (rat brain) and A2 (human platelet) receptors.In addition, these compounds reverse contractions of guinea pig tracheal cylindrical segments induced by potassium chloride, histamine, acetylcholine, and 5-hydroxytryptamine, as well as reverse bronchospasm induced by aerosolized histamine in the conscious guinea pig.
4,6-diacetylresorcinol in heterocyclic synthesis, part i: Synthesis and biological evaluation of some new linearly and angularly substituted pyrano[3,2-g] chromenes via vilsmeier-haack formylation of 4,6- diacetylresorcinol, its schiff bases, and hydrazones
Ali, Tarik E.,Ibrahim, Magdy A.,El-Gendy, Zeinab M.,El-Amin, Eman M.
, p. 3329 - 3341 (2013/10/01)
Application of Vilsmeier-Haack reaction on 4,6-diacetylresorcinol (1) led to the formation of 4,6-dioxo-4H,6H-pyrano[3,2-g]chromene-3,7-dicarboxaldehyde (2) in good yield. The dicarboxaldehyde 2 was condensed with some carbon and nitrogen nucleophiles. Some aliphatic and aromatic Schiff bases of 4,6-diacetylresorcinol (1) were subjected to Vilsmeier-Haack formylation reaction to afford 4,6-bis(alkyl/arylimino)-4H,6H-pyrano[3,2-g]chromene-3,7- dicarbaldehydes 10, 14, and 15. Also, treatment of some bis-hydrazones of 4,6-diacetylresorcinol 16-19 with Vilsmeier-Haack reagent afforded the corresponding 4,6-bis(4-formylpyrazol-3-yl)resorcinols 20 and 21, which underwent oxidation with iodine to yield the pyrano[3,2-g]chromeno[4,3-c:7,6-c] dipyrazole-4,8-diones 22 and 23, respectively. Most of the synthesized compounds revealed weak antimicrobial activities. It was noticed that the dicarboxaldehydes 2, 10, 14, and 15 exhibited moderate antibacterial activity against Gram-positive bacteria, yeast, and fungus. [Supplementary materials are available for this article. Go to the publisher's online edition of Synthetic Communications for the following free supplemental resource(s): Full experimental and spectral details.]
