Benzodipyrazoles: Non-Xanthine Adenosine Antagonists

Article abstract of DOI:10.1021/jm00118a032

3,5-Dimethylbenzo<1,2-c:5,4-c'>dipyrazoles, optionally substituted in the 1-, 7-, and 8-positions, were synthesized from resorcinols.These compounds display affinity for adenosine A₁ (rat brain) and A₂ (human platelet) receptors.In addition, these compounds reverse contractions of guinea pig tracheal cylindrical segments induced by potassium chloride, histamine, acetylcholine, and 5-hydroxytryptamine, as well as reverse bronchospasm induced by aerosolized histamine in the conscious guinea pig.