115762-17-9

Basic information

• Product Name: Ruzadolane
• Synonyms: Ruzadolane;UP 26-91
• CAS NO: 115762-17-9
• Molecular Formula: C18H19F2N5S
• Molecular Weight: 375.445
• Mol File: 115762-17-9.mol
• Article Data: 3

Chemical Properties

• Boiling Point: °Cat760mmHg
• Flash Point: °C
• Appearance: /
• Density: 1.38g/cm³
• Refractive Index: 1.668
• Storage Temp.: Hygroscopic, -20°C Freezer, Under inert atmosphere
• Solubility: Chloroform (Slightly), Methanol (Slightly)
• PKA: 6.06±0.10(Predicted)
• CAS DataBase Reference: Ruzadolane(CAS DataBase Reference)
• NIST Chemistry Reference: Ruzadolane(115762-17-9)
• EPA Substance Registry System: Ruzadolane(115762-17-9)

Safety Data

• Hazardous Substances Data: 115762-17-9(Hazardous Substances Data)

Usage

Uses

Ruzadolane is a non-narcotic, centrally-acting analgesic agent.

InChI:InChI=1/C18H19F2N5S/c19-14-4-5-16(15(20)13-14)24-9-7-23(8-10-24)11-12-26-18-22-21-17-3-1-2-6-25(17)18/h1-6,13H,7-12H2

Upstream product

• 280-57-9 1,4-diaza-bicyclo[2.2.2]octane 
• 367-23-7 1,2,4-trifluorobenzene 
• 6952-68-7 1,2,4-triazolo<4,3-a>pyridin-3-thiol 
• 5308-25-8 4-ethylpiperazine 

Relevant articles and documents

Multicomponent Reactions with Cyclic Tertiary Amines Enabled by Facile C?N Bond Cleavage

A novel and catalyst-free multicomponent reaction with cyclic tertiary amines, electron-deficient aryl halides or heteroaromatic halides, and Na2S enabled by facile C?N bond cleavage of the cyclic tertiary amines was developed. This direct and operationally simple method can be applied with a wide range of functional groups and provides an efficient and rapid approach to potentially drug-like products containing amine, azaarene, thioether, or phenol ether functionalities in good to excellent yields. The utility of this method was demonstrated by the rapid synthesis of the analgesic ruzadolane.

Novel aminoalkylthio derivatives of triazolopyridine or triazoloquinoline, the processes for their preparation, and drugs, useful especially as analgesics, in which they are present

The present invention relates to novel compounds corresponding to the formula: STR1 in which: n represents an integer between 1 and 8 and optimally 2 or 3; (CH2)n --N can also form a ring or a heterocycle, for example having 5 to 7 atoms and preferably 6 atoms; R1 and R2 can represent hydrogen or a lower alkyl having 1 to 5 carbon atoms or can form, together with the nitrogen, a ring such as pyrrolidine, piperidine, morpholine, thiomorpholine, phenyltetrahydropyridine, piperazine or piperazine N-substituted by an alkyl, a phenyl or a heterocycle; in the case of the phenyltetrahydropyridines and the phenylpiperazines or heteroarylpiperazines, the phenyl or the heterocycle may or may not be substituted by halogens or methoxy, thiomethyl, hydroxyl, nitro, amino, cyano, lower alkyl, trifluoromethyl or trichloromethyl groups; and R3, R4 and R5 can represent hydrogen, a lower alkyl, a hydroxyalkyl or hydroxybenzyl group, a halogen, a trifluoromethyl, a methoxy, a thiomethyl or a nitro or two of them can form a ring, in particular a phenyl in the case of the triazoloquinolines or the triazoloisoquinolines; and the non-toxic acid addition salts. These products are useful as drugs and possess analgesic properties, acting especially on the central nervous system as minor tranquilizers.