6952-68-7

Usage

Uses

Used in Pharmaceutical Industry:
[1,2,4]TRIAZOLO[4,3-A]PYRIDINE-3-THIOL is used as a pharmaceutical intermediate for its potential role in the development of new drugs. Its unique structure allows it to interact with biological targets, potentially leading to the discovery of novel therapeutic agents.
Used in Material Science:
In the field of material science, [1,2,4]TRIAZOLO[4,3-A]PYRIDINE-3-THIOL is utilized as a component in the synthesis of advanced materials. Its incorporation can enhance material properties, such as stability, reactivity, or specific interactions with other molecules, contributing to the creation of innovative materials with tailored characteristics.
Used in Organic Synthesis:
[1,2,4]TRIAZOLO[4,3-A]PYRIDINE-3-THIOL serves as a building block in organic synthesis, enabling the construction of new compounds with desired properties. Its reactivity and structural features make it a valuable precursor for the development of complex organic molecules with applications in various industries, including pharmaceuticals, agrochemicals, and specialty chemicals.

InChI:InChI=1/C6H5N3S/c10-6-8-7-5-3-1-2-4-9(5)6/h1-4H,(H,8,10)

Upstream product

• 4930-98-7 pyrid-2-ylhydrazine 
• 584-10-1 potassium trithiocarbonate 
• 103-72-0 phenyl isothiocyanate 
• 64-17-5 ethanol 
• 64-19-7 acetic acid 
• 120-82-1 1,2,4-Trichlorobenzene 
• 75-15-0 carbon disulfide 
• 109-04-6 2-bromo-pyridine 

Downstream Products

• 1205852-96-5 4-([1,2,4]triazolo[4,3-a]pyridin-3-ylsulphanyl)aniline 
• 1205853-08-2 phenyl [6-([1,2,4]triazolo[4,3-a]pyridin-3-ylsulphanyl)-1,3-benzothiazol-2-yl]carbamate 
• 115762-17-9 3-((2-(4-(2,4-difluorophenyl)-piperazin-1-yl)ethyl)thio)-[1,2,4]triazolo[4,3-a]pyridine 
• 1205852-97-6 3-[(4-nitrophenyl)sulphanyl][1,2,4]triazolo[4,3-a]pyridine 
• 124435-44-5 3-{2-[5-(4-Methoxy-phenyl)-[1,3,4]oxadiazol-2-yl]-ethylsulfanyl}-[1,2,4]triazolo[4,3-a]pyridine 
• 124435-45-6 3-{2-[5-(4-Chloro-phenyl)-[1,3,4]oxadiazol-2-yl]-ethylsulfanyl}-[1,2,4]triazolo[4,3-a]pyridine 
• 124453-95-8 3-[2-(5-p-Tolyl-[1,3,4]oxadiazol-2-yl)-ethylsulfanyl]-[1,2,4]triazolo[4,3-a]pyridine 
• 124435-46-7 3-[2-(5-m-Tolyl-[1,3,4]oxadiazol-2-yl)-ethylsulfanyl]-[1,2,4]triazolo[4,3-a]pyridine 
• 124435-43-4 3-<(5-phenyl-1,3,4-oxadiazol-2-yl)ethylthio>-1,2,4-triazolo<4,3-a>pyridine 

Relevant academic research and scientific papers

Identification and in-vitro ADME assessment of a series of novel anti-malarial agents suitable for hit-to-lead chemistry

Triage of a set of antimalaria hit compounds, identified through high throughput screening against the Chloroquine sensitive (3D7) and resistant (Dd2) parasite Plasmodium falciparum strains identified several novel chemotypes suitable for hit-to-lead chemistry investigation. The set was further refined through investigation of their in vitro ADME properties, which identified templates with good potential to be developed further as antimalarial agents. One example was profiled in an in vivo murine Plasmodium berghei model of malaria infection.

X-ray crystal structure guided discovery of new selective, substrate-mimicking sirtuin 2 inhibitors that exhibit activities against non-small cell lung cancer cells

Human sirtuin 2 (SIRT2) is a nicotinamide adenine dinucleotide (NAD+)-dependent deacylase, and is implicated in human diseases including cancer. Selective small-molecule inhibitors for SIRT2 are sought as chemical tools and potential therapeuti

Antiviral imidazo- and triazolo-pyridines

Thioacetonitrile of imidazo- and triazolo pyridines and their use as antiviral agents are disclosed.