115767-63-0Relevant academic research and scientific papers
One-pot conversion of α-ureido and α-thioureido esters to imidazol-2-ones and imidazole-2-thiones
Markwalder, Jay A.,Pottorf, Richard S.,Seitz, Steven P.
, p. 521 - 522 (1997)
4-Hydroxyimidazolidin-2-ones and 4-hydroxyimidazolidine-2-thiones are obtained by treatment of N-(aminocarbonyl)-α-amino esters and N-(aminothiocarbonyl)-α-amino esters with diisobutylaluminum hydride (DIBAH). These substances are transformed to imidazol-2-ones and imidazole-2-thiones upon acidic workup.
T-CELL INHIBITING COMPOUNDS AND THEIR USE FOR THE TREATMENT OF T-CELL-MEDIATED DISEASES
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Page/Page column 30; 39, (2008/12/07)
The present invention relates to compounds of formula IA or IB. The present invention also concerned to a method of treating immunologic diseases or pathological conditions in association with T cell involving an immunologic component using T-cell inhibitors, optionally in combination with one or more other drugs selected from steroids, DMARDs, NSAIDs, immunosuppressive, and biological modifiers, pharmaceutical compositions comprising said compounds of formula IA or IB together with said other drugs, and the use of T-cell inhibitors for the manufacture of a pharmaceutical composition for the treatment of immunologic diseases or pathological conditions involving an immunologic component.
