115795-02-3

Basic information

• Product Name: D-Proline, 1-benzoyl-
• Synonyms: .Bz-D-Pro-OH;D-N-benzoylproline
• CAS NO: 115795-02-3
• Molecular Formula: C12H13NO3
• Molecular Weight: 219.24
• Mol File: 115795-02-3.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: D-Proline, 1-benzoyl-(CAS DataBase Reference)
• NIST Chemistry Reference: D-Proline, 1-benzoyl-(115795-02-3)
• EPA Substance Registry System: D-Proline, 1-benzoyl-(115795-02-3)

Safety Data

• Hazardous Substances Data: 115795-02-3(Hazardous Substances Data)

Upstream product

• 98-88-4 benzoyl chloride 
• 344-25-2 D-Prolin 
• 609-36-9 rac-Pro-OH 
• 195719-48-3 N-benzoylproline 

Downstream Products

• 115795-01-2 (R)-2-[((R)-1-Benzoyl-pyrrolidine-2-carbonyl)-amino]-3-phenyl-propionic acid 

Relevant articles and documents

Identification of Novel Fragments Binding to the PDZ1-2 Domain of PSD-95

Inhibition of PSD-95 has emerged as a promising strategy for the treatment of ischemic stroke, as shown with peptide-based compounds that target the PDZ domains of PSD-95. In contrast, developing potent and drug-like small molecules against the PSD-95 PDZ domains has so far been unsuccessful. Here, we explore the druggability of the PSD-95 PDZ1-2 domain and use fragment screening to investigate if this protein is prone to binding small molecules. We screened 2500 fragments by fluorescence polarization (FP) and validated the hits by surface plasmon resonance (SPR), including an inhibition counter-test, and found four promising fragments. Three ligand efficient fragments were shown by 1H,15N HSQC NMR to bind in the small hydrophobic P0 pockets of PDZ1-2, and one of them underwent structure-activity relationship (SAR) studies. Overall, we demonstrate that fragment screening can successfully be applied to PDZ1-2 of PSD-95 and disclose novel fragments that can serve as starting points for optimization towards small-molecule PDZ domain inhibitors.

Aldehyde-containing chiral amine recognition probe and preparation method and application thereof

The invention discloses an aldehyde-containing chiral amine recognition probe (BPBr) and a preparation method and an application thereof; the aldehyde-containing chiral amine recognition probe has chiral kinetics difference, chiral amine substances in a complex matrix can be separated and quantitatively analyzed by a liquid chromatography-mass spectrometry technology, and primary amine compounds in the matrix can be subjected to non-target metabolite analysis. The preparation method includes the steps: adding R-proline and potassium carbonate, then adding a tetrahydrofuran solvent, dropping benzoyl chloride in ice-water bath, and carrying out a stirring reaction for 1-5 h at the temperature of 10-40 DEG C in a reaction vessel, to obtain a first-step product; and taking the first-step product, adding 4-bromosalicylaldehyde, dicyclohexylcarbodiimide and 4-dimethylaminopyridine, adding dichloromethane as a solvent, and carrying out a reaction for 1 h-5 h at the temperature of 30 DEG C-50DEG C, to obtain the aldehyde-containing chiral amine recognition probe (BPBr).