115796-72-0

Upstream product

• 75-77-4 chloro-trimethyl-silane 
• 115757-29-4 (1S,2R)-(+)-N-methylephedrine butyrate 

Downstream Products

• 120419-82-1 (2R,3S)-2-Ethyl-3-hydroxy-succinic acid 1-((1S,2R)-2-dimethylamino-1-phenyl-propyl) ester 4-ethyl ester 
• 120521-13-3 (2R,3R)-2-Ethyl-3-hydroxy-succinic acid 1-((1S,2R)-2-dimethylamino-1-phenyl-propyl) ester 4-ethyl ester 
• 120419-90-1 2-Benzylamino-3-ethyl-succinic acid 4-((1S,2R)-2-dimethylamino-1-phenyl-propyl) ester 1-ethyl ester 
• 115757-20-5 (2R,3S,4S)-5-Benzyloxy-2-ethyl-3-hydroxy-4-methyl-pentanoic acid (1S,2R)-2-dimethylamino-1-phenyl-propyl ester 
• 120419-93-4 2-Ethyl-3-(4-methoxy-phenylamino)-succinic acid 1-((1S,2R)-2-dimethylamino-1-phenyl-propyl) ester 4-ethyl ester 
• 120419-71-8 (E)-(2R,3R)-2-Ethyl-3-hydroxy-5-phenyl-pent-4-enoic acid (1S,2R)-2-dimethylamino-1-phenyl-propyl ester 
• 120521-06-4 (E)-(2R,3S)-2-Ethyl-3-hydroxy-5-phenyl-pent-4-enoic acid (1S,2R)-2-dimethylamino-1-phenyl-propyl ester 

Relevant academic research and scientific papers

TiCl4-MEDIATED REACTIONS OF SILYL KETENE ACETALS DERIVED FROM N-METHYLEPHEDRINE ESTERS: ASYMMETRIC SYNTHESIS OF β-LACTAMS

TiCl4 mediated addition of silyl ketene acetals derived from N-methylephedrine esters to various aldehydes and imines was used as the key-step in the enantio- and diastereo-controlled synthesis of β-lactams.Thus 3,4-trans and cis substituted-2-azetidinone

Chelation-Controlled Enantioselective Synthesis of Key Intermediates for the Preparation of Carbapenem Antibiotics PS-5 and 1β-Methyl-PS-5

Reaction of the E silyl ketene acetal derived from (1S,2R)-N-methylephedrine butyrate (7) with TiCl4 and β-alkoxy aldehyde 5 gave the aldol product in 75percent yield as a 78:11:11 mixture of stereoisomers.In agreement with a chelated transition structure