115797-39-2Relevant academic research and scientific papers
I2/Li2CO3-promoted cyanation of diarylalcohols through a dual activation process
Hu, Liangzhen,Hussain, Muhammad Ijaz,Deng, Qingfu,Liu, Qing,Feng, Yangyang,Zhang, Xiaohui,Xiong, Yan
, p. 308 - 314 (2018/12/11)
One-step base promoted strategy for cyanation of α,α-diaryl alcohols has been developed under mild and transition metal-free conditions. This method provides a straightforward and facile way towards the synthesis of β,γ-unsaturated nitriles and α-phenylnitiriles from α-vinyl carbinols and α,α-diaryl methanols, respectively, up to 99% yield. Moreover, various azides and ethers could also be accessed from their respective nucleophiles under standard reaction conditions.
A Novel Darzens-Type Condensation Using α-Chloro Ketimines
Sulmon, Paul,Kimpe, Norbert De,Schamp, Niceas,Declercq, Jean-Paul,Tinant, Bernard
, p. 4457 - 4462 (2007/10/02)
3-Chloro-1-azaallylic anions, generated by deprotonation of α-chloro ketimines with lithium diisopropylamide, reacted with ketones and aldehydes to produce 2-imidoyloxiranes (α,β-epoxy ketimines).This novel aza-Darzens-type condensation allows α-chloro ketones to condense with carbonyl compounds via protection as α-chloroketimines.The aza-Derzens-type reaction with benzophenones as carbonyl substrate proceeded via Favorskii-like rearrangement of an intermediate α,β-epoxy ketimine, the intermediate cyclopropylideneamine being trapped in an intramolecular way.Subsequent ring opening of the bicyclic intermediate adduct according to a so-called abnormal opening furnished rearranged 3-butenenamide derivatives.
