1158076-89-1Relevant academic research and scientific papers
Rhodium-Catalyzed Regio- and Enantioselective Addition of N-Hydroxyphthalimide to Allenes: A Strategy to Synthesize Chiral Allylic Alcohols
Liu, Zi,Breit, Bernhard
, p. 300 - 303 (2018/01/17)
We achieved the first Rh-catalyzed regio- and enantioselective additions of N-hydroxyphthalimide to allenes. This transformation is accomplished via mild reaction conditions, leveraging on Josiphos SL-J003-2 as a chiral ligand to furnish branched O-allyl compounds in good yields with moderate to excellent enantioselectivities. The substrate scope is broad, and various functional groups are tolerated. The utility of this methodology is elaborated by transformation to allylic alcohols with different functional groups as well as to chiral O-allyl hydroxylamines.
Concise synthesis of stagonolide-F by ring closing metathesis approach and its biological evaluation
Perepogu, Arun Kumar,Raman,Murty,Rao, Vaidya Jayathirtha
experimental part, p. 46 - 51 (2009/08/07)
The first total synthesis of 9-membered macrolide, stagonolide-F (3), starting from commercially available 1,5-pentane diol is reported. A combination of Jacobsen's hydrolytic kinetic resolution (HKR) and Sharpless epoxidation is used for the creation of two stereogenic centers, while ring-closing metathesis (RCM) strategy was used for the construction of the lactone ring. The molecule synthesized exhibited potent antifungal, antibacterial and cytotoxic activities against all the tested strains.
