1158127-10-6

Basic information

• Product Name: C₁₁H₁₂BrNO₂
• CAS NO: 1158127-10-6
• Molecular Weight: 270.126
• Mol File: 1158127-10-6.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₁₁H₁₂BrNO₂(CAS DataBase Reference)
• NIST Chemistry Reference: C₁₁H₁₂BrNO₂(1158127-10-6)
• EPA Substance Registry System: C₁₁H₁₂BrNO₂(1158127-10-6)

Safety Data

• Hazardous Substances Data: 1158127-10-6(Hazardous Substances Data)

Upstream product

• 7345-79-1 2-bromocinnamic acid 
• 141-43-5 ethanolamine 

Relevant articles and documents

Synthesis and anticonvulsant activity of N-(2-hydroxyethyl) cinnamamide derivatives

A series of novel N-(2-hydroxyethyl) cinnamamide derivatives were synthesized and screened for their anticonvulsant activities by the maximal electroshock (MES) test and their neurotoxicity was evaluated by the rotarod neurotoxicity test (Tox). The MES test showed that compounds I(N-(2-hydroxyethyl) cinnamamide) and 1d ((E)-3-(3-fluorophenyl)-N-(2-hydroxyethyl)acrylamide) were found to possess better anticonvulsant activity but also had lower toxicity. In the anti-MES potency test, these compounds exhibited median effective dose (ED50) of 17.7 and 17.0 mg/kg, respectively, and median toxicity dose (TD50) of 154.9 and 211.1, respectively, resulting in a protective index (PI) of 8.8 and 12.4, respectively, which is much greater than the PI of the marked antiepileptic drug carbamazepine. To further investigate the effects of the anticonvulsant activity in several different models, compounds I and 1d were tested against convulsions induced by chemical substances, including pentylenetetrazole (PTZ), isoniazid, 3-mercaptopropionic acid, and thiosemicarbazide.