115884-45-2Relevant academic research and scientific papers
Synthesis of new inhibitors of aldosterone biosynthesis
Viger, Antoinette,Coustal, Suzy,Perard, Serge,Marquet, Andree
, p. 1127 - 1134 (1988)
The synthesis of 18 vinyl and 18 ethynylprogesterone 1 and 2 is described. The reported data emphasize the decisive role played by the protective group on carbon 3 in the course of reactions taking place at the angular 18 methyl group. Compounds 1 and 2, designed as kcat inhibitors of aldosterone biosynthesis late step show substantial in vitro activity.
