Tetrahedron p. 1127 - 1134 (1988)
Update date:2022-08-02
Topics:
Viger, Antoinette
Coustal, Suzy
Perard, Serge
Marquet, Andree
The synthesis of 18 vinyl and 18 ethynylprogesterone 1 and 2 is described. The reported data emphasize the decisive role played by the protective group on carbon 3 in the course of reactions taking place at the angular 18 methyl group. Compounds 1 and 2, designed as kcat inhibitors of aldosterone biosynthesis late step show substantial in vitro activity.
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